# US 7,612,225 B2 · Crystal of triterpene derivative

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- Number: US 7,612,225 B2
- Document ID: US7612225B2
- Status: Granted
- Kind: B2
- Application number: 10/592,540
- Filed: 2005-03-24
- Published: 2007-12-06
- Granted: 2009-11-03
- Earliest claimed: 2004-03-24
- Assignees: Shionogi & Co., Ltd.
- Inventors: Masataka Fumoto
- Web page: https://patentgrep.com/patent/US7612225B2

## CPC

- C07C 231/22: Separation; Purification; Stabilisation; Use of additives (separation of optical isomers C07C231/20)
- A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/12: Antihypertensives
- A61P 11/06: Antiasthmatics
- A61P 13/12: of the kidneys
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07J 63/008: {Expansion of ring D by one atom, e.g. D homo steroids}
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07J: STEROIDS (seco-steroids C07C)

## Abstract

Disclosed herein are a novel crystal of a novel triterpene derivative, a method for producing the crystals, and a pharmaceutical preparation obtained by using the crystals. The novel crystal is a crystal of a compound (I) of the formula (I):

## Claims

### Claim 1

A crystal of a compound of the formula (I):
which exhibits a powder X-ray diffraction pattern having main peaks at diffraction angles (2θ) of 6.0, 6.5, 12.6, 13.6, and 15.4 (degree).

### Claim 2 (depends on 1)

A method for producing the crystals as claimed in claim 1 comprising suspending or dissolving crystals of a compound of the formula (I):
which exhibit a powder X-ray diffraction pattern having main peaks at diffraction angles (2θ) of 4.6, 7.7, 12.7, 16.7, 19.1 and 21.1 (degree) in acetonitrile to change their crystal form.

### Claim 3 (depends on 1)

A method for producing a pharmaceutical preparation comprising mixing the crystals as claimed in claim 1, a solvent, and sodium hydroxide, and drying the mixture.