# US 7,612,192 B2 · Neisseria genomic sequences and methods of their use

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- Number: US 7,612,192 B2
- Document ID: US7612192B2
- Status: Granted
- Kind: B2
- Application number: 10/915,740
- Filed: 2004-08-11
- Published: 2005-09-01
- Granted: 2009-11-03
- Earliest claimed: 2001-09-06
- Assignees: Novartis Vaccines and Diagnostics, Inc.; J. Craig Venter Institute, Inc.
- Inventors: Claire Marie Fraser; Erin Kathleen Hickey; Jeremy D. Peterson; Herve Tettelin; Craig Ventor; Vega Masignani; Cesira Galeotti; Marirosa Mora; Giulio Ratti; Maria Scarselli; Vincenzo Scarlato; Rino Rappuoli; Mariagrazia Pizza; Guido Grandi
- Web page: https://patentgrep.com/patent/US7612192B2

## CPC

- C07K 14/22: from Neisseriaceae (F)
- A61P 31/04: Antibacterial agents
- C12Q 1/689: for bacteria
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- C12Q 2600/156: Polymorphic or mutational markers
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.

## Claims

### Claim 1

An isolated and purified polynucleotide comprising the nucleotide of SEQ ID NO 35.

### Claim 2

An isolated and purified polynucleotide comprising a nucleotide sequence having greater than 70% sequence identity to SEQ ID NO 35.

### Claim 3

An isolated and purified polynucleotide which encodes a protein, wherein the polynucleotide comprises the nucleotide sequence of SEQ ID NO 35 or a complement thereof.

### Claim 4

An isolated and purified polynucleotide which encodes a protein, wherein the polynucleotide comprises a nucleotide sequence having greater than 70% sequence identity to SEQ ID NO 35 or a complement thereof.