# US 7,612,191 B2 · Polynucleotides encoding interleukin-17 receptor homologue

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- Number: US 7,612,191 B2
- Document ID: US7612191B2
- Status: Granted
- Kind: B2
- Application number: 11/537,892
- Filed: 2006-10-02
- Published: 2007-02-15
- Granted: 2009-11-03
- Earliest claimed: 1999-07-07
- Assignees: ZymoGenetics, Inc.
- Inventors: Scott R. Presnell; Steven K. Burkhead; Sarah L. Pownder
- Web page: https://patentgrep.com/patent/US7612191B2

## CPC

- C07K 14/7155: {for interleukins [IL]}
- C07K 14/7156: {for interferons [IFN]}
- C07K 2319/00: Fusion polypeptide
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”

## Claims

### Claim 1

An isolated polynucleotide that encodes a Zcytor14 polypeptide comprising amino acid residues 21 to 452 of SEQ ID NO:2.

### Claim 2 (depends on 1)

The isolated polynucleotide of claim 1, wherein the polynucleotide comprises a nucleotide sequence selected from the group consisting of: SEQ ID NO:1 and SEQ ID NO:3.

### Claim 3 (depends on 1)

The isolated polynucleotide of claim 1, wherein the polynucleotide encodes a polypeptide comprising an amino acid sequence selected from the group consisting of:
(a) amino acid residues 21 to 677 of SEQ ID NO:2, and
(b) amino acid residues 1 to 692 of SEQ ID NO:2.

### Claim 4 (depends on 1)

The isolated polynucleotide of claim 1, wherein the encoded polypeptide consists of an amino acid sequence selected from the group consisting of:
(a) amino acid residues 21 to 452 of SEQ ID NO:2,
(b) amino acid residues 21 to 677 of SEQ ID NO:2, and
(c) amino acid residues 1 to 692 of SEQ ID NO:2.

### Claim 5

An isolated polynucleotide consisting of a nucleotide sequence selected from the group consisting of: (a) SEQ ID NO:1, and (b) SEQ ID NO:3.

### Claim 6

An isolated polynucleotide that encodes a fusion protein, said fusion protein comprising:
amino acid residues 21 to 452 of SEQ ID NO:2; and
an immunoglobulin heavy chain constant region.

### Claim 7 (depends on 6)

The isolated polynucleotide of claim 6, wherein the immunoglobulin heavy chain constant region is an Fc fragment.

### Claim 8 (depends on 7)

The isolated polynucleotide of claim 7, wherein the Fc fragment is a human Fc fragment.

### Claim 9

An isolated polynucleotide that encodes a polypeptide comprising at least 100 contiguous amino acid residues of the polypeptide consisting of amino acid residues 21 to 452 of SEQ ID NO:2.