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US 7,612,181 B2Granted
Dual variable domain immunoglobulin and uses thereof
AssigneeAbbott Laboratories
InventorsChengbin Wu, Tariq Ghayur, Richard W. Dixon, Jochen G. Salfeld
Life of this patent
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Abstract
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
Claims43
A binding protein comprising four polypeptide chains, wherein two polypeptide chains comprise VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first heavy chain variable domain, VD2 is a second heavy chain variable domain, C is a heavy chain constant domain, X1 is a linker with the proviso that it is not CH1, and X2 is an Fc region;
- and two polypeptide chains comprise VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first light chain variable domain, VD2 is a second light chain variable domain, C is a light chain constant domain, X1 is a linker with the proviso that it is not CH1, and X2 does not comprise an Fc region;
- and n is 0 or 1;
- wherein said four polypeptide chains of said binding protein form four functional antigen binding sites.
Dependencies are inferred from the claim text.