Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
AssigneeVifor (International) AG
InventorsPeter Geisser, Erik Philipp, Walter Richle
Life of this patent
Estimating the term…
Abstract
Water soluble iron carbohydrate complex obtainable from an aqueous solution of iron (III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and medicament for the treatment and prophylaxis of iron deficiency conditions.
Claims27
A water soluble iron carbohydrate complex having a weight average molecular weight (Mw) of 80,000 to 400,000, comprising the reaction product of:
- (a) an aqueous solution of an iron (III) salt and
- (b) an aqueous solution of the oxidation product of
- (i) at least one maltodextrin and
- (ii) an aqueous hypochlorite solution at an alkaline pH, wherein,
- when one maltodextrin is present, the maltodextrin has a dextrose equivalent of between 5 and 20, and wherein,
- when a mixture of more than one maltodextrin is present, the dextrose equivalent of each individual maltodextrin is between 2 and 40, and the dextrose equivalent of the mixture is between 5 and 20.
A process for producing a water soluble iron carbohydrate complex having a weight average molecular weight (Mw) of 80,000 to 400,000, comprising the steps of:
- (a) oxidizing at least one maltodextrin in an aqueous solution at an alkaline pH with an aqueous hypochlorite solution to form an oxidized maltodextrin solution, and
- (b) contacting the oxidized maltodextrin solution with an aqueous solution of an iron (III) salt, wherein,
- when one maltodextrin is present, the maltodextrin has a dextrose equivalent of between 5 and 20, and wherein,
- when a mixture of more than one maltodextrin is present, the dextrose equivalent of each individual maltodextrin is between 2 and 40, and the dextrose equivalent of the mixture is between 5 and 20.
A process for producing a water soluble iron carbohydrate complex having a weight average molecular weight (Mw) of 80,000 to 400,000, comprising the steps of:
- (a) oxidizing at least one maltodextrin in an aqueous solution at a pH in the range of 8 to 12 and a temperature in the range of 15 to 40° C., for 10 minutes to 4 hours with an aqueous hypochlorite solution to form an oxidized maltodextrin solution,
- (b) contacting the oxidized maltodextrin solution with an aqueous solution of an iron (III) salt and
- (c) raising the pH of the oxidized maltodextrin solution and iron (III) salt to a value in the range of 5 to 14, wherein,
- when one maltodextrin is present, the maltodextrin has a dextrose equivalent of between 5 and 20, and wherein,
- when a mixture of more than one maltodextrin is present, the dextrose equivalent of each individual maltodextrin is between 2 and 40, and the dextrose equivalent of the mixture is between 5 and 20.
Dependencies are inferred from the claim text.