# US 7,612,094 B2 · Tri-substituted heteroaryls and methods of making and using the same

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- Number: US 7,612,094 B2
- Document ID: US7612094B2
- Status: Granted
- Kind: B2
- Application number: 10/510,459
- Filed: 2003-04-04
- Published: 2006-03-23
- Granted: 2009-11-03
- Earliest claimed: 2002-04-04
- Assignees: Biogen Idec MA Inc.
- Inventors: Wen-Cherng Lee; Lihong Sun; Feng Shan; Claudio Chuaqui; Zhongli Zheng; Russell C. Petter
- Web page: https://patentgrep.com/patent/US7612094B2

## CPC

- C07D 471/04: Ortho-condensed systems
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 13/00: Drugs for disorders of the urinary system
- A61P 13/12: of the kidneys
- A61P 17/00: Drugs for dermatological disorders
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 27/02: Ophthalmic agents
- A61P 35/00: Antineoplastic agents
- A61P 35/04: specific for metastasis
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07D 401/14: containing three or more hetero rings
- C07D 405/14: containing three or more hetero rings
- C07D 413/14: containing three or more hetero rings
- C07D 417/14: containing three or more hetero rings
- C07D 453/00: Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D 487/08: Bridged systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).

## Claims

### Claim 1

A compound of the following formula:
or an N-oxide or a pharmaceutically acceptable salt thereof,
wherein
R1 is aryl, heteroaryl, aralkyl, or heteroaralkyl;
each Ra is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
X is piperidinyl, piperazinyl, pyrrolidinyl, tetrahydrofuran, cyclohexyl, cyclopentyl, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, bicyclo[3.2.1]octane, 2-oxa-bicyclo[2.2.2]octane, 2-aza-bicyclo[2.2.2]octane, 3-aza-bicyclo[3.2.1]octane, or 1-aza-bicyclo[2.2.2]octane;
Y is a bond, —C(O)—, —C(O)—O—, —O—C(O)—, —S(O)p—O—, —O—S(O)p—, —C(O)—N(Rb)—, —N(Rb)—C(O)—, —O—C(O)—N(Rb)—, —N(Rb)—C(O)—O—, —O—S(O)p—N(Rb)—, —N(Rb)—S(O)p—O—, —N(Rb)—C(O)—N(Rc)—, —N(Rb)—S(O)p—N(Rc)—, —C(O)—N(Rb)—S(O)p—, —S(O)p—N(Rb)—C(O)—, —C(O)—N(Rb)—S(O)p—N(Rc)—, —C(O)—O—S(O)p—N(Rb)—, —N(Rb)—S(O)p—N(Rc)—C(O)—, —N(Rb)—S(O)p—O—C(O)—, —S(O)p—N(Rb)—, —N(Rb)—S(O)p—, —N(Rb)—, —S(O)p—, —O—, —S—, or —(C(Rb)(Rc))q—, wherein each of Rb and Rc is independently hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; p is 1 or 2; and q is 1-4;
R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl;
each of A1 and A2, independently, is O, S, N, or NRb; provided that at least one of A1 and A2 is N; and
m is 0, 1, 2, or 3; provided that when m≧2, two adjacent Ra groups can join together to form a 4- to 8-membered optionally substituted cyclic moiety.

### Claim 2 (depends on 1)

The compound of claim 1, wherein X is piperidinyl, piperazinyl, or pyrrolidinyl.

### Claim 3 (depends on 2)

The compound of claim 2, wherein the piperdinyl, piperazinyl, or pyrrolidinyl is bonded to Y via its nitrogen ring atom.

### Claim 4 (depends on 1)

The compound of claim 1, wherein X is cyclohexyl, cyclopentyl, or bicyclo[2.2.2]octane.

### Claim 5 (depends on 4)

The compound of claim 4, wherein Y is —N(Rb)—C(O)—, —N(Rb)—S(O)2—, —C(O)—, —C(O)—O—, —O—C(O)—, —C(O)—N(Rb)—, —S(O)p—, —O—, —S(O)2—N(Rb)—, —N(Rb)—, —N(Rb)—C(O)—O—, or —N(Rb)—C(O)—N(Rc)—.

### Claim 6 (depends on 1)

The compound of claim 1, wherein m is 0-2; R1 is aryl or heteroaryl; R2 is hydrogen, C1-6 alkyl, aryl, heteroaryl, —C1-4 alkyl-aryl, or —C1-4 alkyl-heteroaryl; X is piperidinyl, piperazinyl, pyrrolidinyl, tetrahydrofuran, cyclohexyl, cyclopentyl, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, bicyclo[3.2.1]octane, 2-oxa-bicyclo[2.2.2]octane, 2-aza-bicyclo[2.2.2]octane, 3-aza-bicyclo[3.2.1]octane, or 1-aza-bicyclo[2.2.2]octane; and Y is —N(Rb)—C(O)—, —N(Rb)—S(O)2—, —C(O)—, —C(O)—O—, —O—C(O)—, —C(O)—N(Rb)—, —S(O)p—, —O—, —S(O)2—N(Rb)—, —N(Rb)—, —N(Rb)—C(O)—O—, —N(Rb)—C(O)—N(Rc)—, —C(O)—N(Rb)—S(O)p—N(Rc)—, or —C(O)—O—S(O)p—N(Rb)—.

### Claim 7 (depends on 1)

The compound of claim 1, wherein m is 0-2; R1 is aryl or heteroaryl; R2 is hydrogen, C1-6 alkyl, aryl, heteroaryl, —C1-4 alkyl-aryl, or —C1-4 alkyl-heteroaryl; and —X—Y— is

### Claim 8 (depends on 7)

The compound of claim 7, wherein A1 is N and A2 is NH, or A1 is NH and A2 is N.

### Claim 9 (depends on 8)

The compound of claim 8, wherein R1 is substituted phenyl.

### Claim 10 (depends on 9)

The compound of claim 9, wherein R2 is hydrogen, C1-4 alkyl, benzyl, or pyridylmethyl.

### Claim 11 (depends on 10)

The compound of claim 10, wherein m is 1 and Ra is is substituted at the 6-position.

### Claim 12 (depends on 1)

The compound of claim 1, wherein m is 0-2; R1 is aryl or heteroaryl; R2 is hydrogen, C1-6 alkyl, aryl, heteroaryl, aryl-C1-4 alkyl, or heteroaryl-C1-4 alkyl; X is cyclohexyl, cyclopentyl, or bicyclo[2.2.2]octane; and Y is —N(Rb)—C(O)—, —N(Rb)—S(O)2—, —C(O)—,
—C(O)—O—, —O—C(O)—, —C(O)—N(Rb)—, —S(O)p—, —O—, —S(O)2—N(Rb)—, —N(Rb)—, —N(Rb)—C(O)—O—, —N(Rb)—C(O)—N(Rc)—, —C(O)—N(Rb)—S(O)p—N(Rc)—, or —C(O)—O—S(O)p—N(Rb)—,
wherein each of Rb and Rc is independently hydrogen or C1-4 alkyl.

### Claim 13 (depends on 12)

The compound of claim 12, wherein A1 is N and A2 is NH, or A1 is NH and A2 is N.

### Claim 14 (depends on 13)

The compound of claim 13, wherein R1 is a substituted phenyl.

### Claim 15 (depends on 14)

The compound of claim 14, wherein R2 is hydrogen, C1-4 alkyl, benzyl, or pyridylmethyl.

### Claim 16 (depends on 15)

The compound of claim 15, wherein m is 1 and Ra is substituted at the 6-position.

### Claim 17 (depends on 1)

The compound of claim 1, said compound being selected from the group consisting of:
4-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-sulfonyl]-benzoic acid;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-fluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-2-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-3-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-4-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(thiophene-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(1-methyl-1H-imidazole-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(5-methyl-isoxazole-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-C-phenyl-methanesulfonamide;
butane-1-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-C-pyridin-2-yl-methanesulfonamide;
thiophene-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
1-methyl-1H-imidazole-4-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(thiophene-3-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-ethyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanol;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonitrile;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-ethyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-C-pyridin-2-yl-methanesulfonamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[4-(1H-tetrazol-5-yl)-bicyclo[2.2.2]oct-1-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetamide;
thiophene-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
1-methyl-1H-imidazole-4-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
thiophene-3-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
methanesulfonic acid 4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetonitrile;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetic acid;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl}-C-pyridin-2-yl-methanesulfonamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
1-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-sulfonylmethyl}-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methylamide;
2-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl ]-piperidine-1-sulfonylmethyl}-phenylamine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (1-methyl-5-methylsulfanyl-1H-[1,2,4]triazol-3-yl)-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid dimethylamide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-(3-chloro-phenyl)-methanone;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-cyclopropyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methoxy-amide;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-carbamic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydrazide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-acetamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-C-phenyl-methanesulfonamide;
butane-1-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-amide;
propane-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-amide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-C-pyridin-2-yl-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-methanesulfonamide;
4-[5-(6-methyl-pyridin-2-yl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[5-(6-methyl-pyridin-2-yl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[4-(6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
4-[4-(6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octan-1-ol;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-sulfamide;
sulfamic acid 4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl ester;
{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-carbamic acid benzyl ester;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonyl}-benzenesulfonamide;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-acetamide;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-methanesulfonamide;
2,2,2-trifluoro-N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-acetamide;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
N-{4-[5-(6-methyl-pyridin-2-yl)-4-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanesulfonamide;
N-{4-[5-(6-methyl-pyridin-2-yl)-4-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetamide;
4-[4-(5-fluoro-6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 4-nitro-benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[l1-(4-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,4-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
3-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
3-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-4-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-3-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
3-[4-benzo[1,3]dioxol-5-yl-1-hydroxy-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid benzyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-carbamic acid benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[l-(butane-1-sulfonyl)-piperidin-3-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
{4-[2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-pyridin-2-yl}-(4-methoxy-benzyl)-amine;
4-[2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-pyridin-2-ylamine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(5-methyl-2-trifluoromethyl-furan-3-sulfonyl-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[2-(1-phenylmethanesulfonyl-piperidin-4-yl)-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-pyridin-2-ylfluoride;
(4-methoxy-benzyl)-{4-[5-(6-methyl-pyridin-2-yl)-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-1H-imidazol-4-yl]-pyridin-2-yl}-amine;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-carbamic acid benzyl ester;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-bromo-pyridine;
1-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-3-phenyl-propan-1-one;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-C-phenyl-methanesulfonamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl}-C-phenyl-methanesulfonamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (pyridin-2-ylmethyl)-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (furan-2-ylmethyl)-amide;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-methanesulfonyl-pyrrolidin-3-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-pyrrolidin-3-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(1-methyl-1H-imidazole-4-sulfonyl)-pyrrolidin-3-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-pyrrolidin-3-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid ethylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid butylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid isopropylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (3-imidazol-1-yl-propyl)-amide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-pyrrolidin-1-yl-methanone;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid diethylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylamine;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-C-pyridin-4-yl-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-2,2,2-trifluoro-acetamide;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid benzyl ester;
2-(5-benzo[1,3]dioxol-5-yl-2-piperidin-4-yl-3H-imidazol-4-yl)-pyridine;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 2-chloro-benzyl ester;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 4,5-dimethoxy-2-nitro-benzyl ester;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 3-fluoro-benzylamide;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 4-fluoro-benzylamide;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid benzylamide;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 4-methyl-benzylamide;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 4-methoxy-benzylamide;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 2,4-dichloro-benzylamide;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 2-chloro-benzylamide;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid amide;
4-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-sulfonyl]-benzonitrile;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
{5-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-sulfonyl]-naphthalen-1-yl}-dimethyl-amine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-pyridin-4-ylmethyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-methoxy-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
1-{4-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-sulfonyl]-phenyl}-ethanone;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-furan-2-ylmethyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-methyl-benzyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3-fluoro-5-trifluoromethyl-benzyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-cyclohexylmethyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyridine;
2-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidin-1-ylmethyl]-cyclopropanecarboxylic acid ethyl ester;
2-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidin-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
1-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidin-1-yl]-2-methyl-propan-2-ol;
2-(6-amino-3-imino-3H-xanthen-9-yl)-4-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carbonyl]-benzoic acid;
1-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidin-1-yl]-ethanone;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl ]-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
1-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-sulfonylmethyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-p-tolylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyridine;
3-(4-benzo[1,3]dioxol-5-yl-1-hydroxy-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-methoxy-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-naphthalen-1-yl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4-yl]-pyridine;
3-[4-benzo[1,3]dioxol-5-yl-1-hydroxy-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
3-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid benzyl ester;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-bis-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(biphenyl-4-sulfonyl)-piperidin-4-yl]-5H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(biphenyl-4-ylmethanesulfonyl)-piperidin-4-yl]-5H-imidazol-4-yl}-pyridine;
4-[5-benzo[1,3]dioxol-5-yl-1-methyl-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-1-methyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-1-hydroxy-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-carbamic acid benzyl ester;
4-[4-(2-chloro-pyridin-4-yl)-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3-phenoxy-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-(2-fluoro-pyridin-4-yl)-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
4-[5-benzo[1,3]dioxol-5-yl-1-hydroxy-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-bromo-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-trifluoromethyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-bromo-pyridin-2-yl)-1-hydroxy-1H-imidazol-2-yl ]-piperidine-1-carboxylic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylamine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(biphenyl-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-phenoxy-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid benzylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid 3-chloro-4-fluoro-benzylamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-chloro-benzenesulfonyl)-pyrrolidin-3-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-naphthalen-2-yl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid cyclohexylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid dipropylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (2-hydroxy-1-methyl-2-phenyl-ethyl)-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (1H-benzoimidazol-2-yl)-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (pyridin-4-ylmethyl)-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid benzothiazol-2-ylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (5,7-difluoro-benzothiazol-2-yl)-amide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-(4-methoxy-phenyl)-methanone; and
{4-[4-benzo[1,3]dioxol-5-yl-1-hydroxy-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-carbamic acid benzyl ester.

### Claim 18 (depends on 1)

The compound of claim 1, said compound being selected from the group consisting of:
4-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-sulfonyl]-benzoic acid;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-fluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-2-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-3-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-4-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[l1-(thiophene-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(1-methyl-1H-imidazole-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(5-methyl-isoxazole-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-C-phenyl-methanesulfonamide;
butane-1-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-C-pyridin-2-yl-methanesulfonamide;
thiophene-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
1-methyl-1H-imidazole-4-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(thiophene-3-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-ethyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanol;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonitrile;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-ethyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-C-pyridin-2-yl-methanesulfonamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[4-(1H-tetrazol-5-yl)-bicyclo[2.2.2]oct-1-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetamide;
thiophene-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
1-methyl-1H-imidazole-4-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
thiophene-3-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
methanesulfonic acid 4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetonitrile;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetic acid;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl}-C-pyridin-2-yl-methanesulfonamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl ]-3H-imidazol-4-yl}-6-methyl-pyridine;
1-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl ]-piperidine-1-sulfonylmethyl}-7,7-dimethyl-bicyclo[2.2. 1]heptan-2-one;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methylamide;
2-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl ]-piperidine-1-sulfonylmethyl}-phenylamine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (1-methyl-5-methylsulfanyl-1H-[1,2,4]triazol-3-yl)-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid dimethylamide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-(3-chloro-phenyl)-methanone;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-cyclopropyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methoxy-amide;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-carbamic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydrazide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-acetamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-C-phenyl-methanesulfonamide;
butane-1-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-amide;
propane-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-amide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-C-pyridin-2-yl-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-methanesulfonamide;
4-[5-(6-methyl-pyridin-2-yl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[5-(6-methyl-pyridin-2-yl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[4-(6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
4-[4-(6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octan-1-ol;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-sulfamide;
sulfamic acid 4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl ester;
{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-carbamic acid benzyl ester;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonyl}-benzenesulfonamide;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-acetamide;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-methanesulfonamide;
2,2,2-trifluoro-N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-acetamide;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
N-{4-[5-(6-methyl-pyridin-2-yl)-4-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanesulfonamide;
N-{4-[5-(6-methyl-pyridin-2-yl)-4-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetamide;
4-[4-(5-fluoro-6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid 4-nitro-benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,4-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
3-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-carboxylic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
3-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-4-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-3-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
3-[4-benzo[1,3]dioxol-5-yl-1-hydroxy-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid benzyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-carbamic acid benzyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3-trifluoromethyl-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-piperidin-3-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-3-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
{4-[2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-pyridin-2-yl}-(4-methoxy-benzyl)-amine;
4-[2-[l-(butane-1-sulfonyl)-piperidin-4-yl]-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-pyridin-2-ylamine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(5-methyl-2-trifluoromethyl-furan-3-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[2-(1-phenylmethanesulfonyl-piperidin-4-yl)-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-pyridin-2-ylfluoride;
(4-methoxy-benzyl)-{4-[5-(6-methyl-pyridin-2-yl)-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-1H-imidazol-4-yl]-pyridin-2-yl}-amine;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-carbamic acid benzyl ester;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-bromo-pyridine;
1-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-3-phenyl-propan-1-one;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-C-phenyl-methanesulfonamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,4-dichloro-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-I -ylmethyl}-C-phenyl-methanesulfonamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (pyridin-2-ylmethyl)-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (furan-2-ylmethyl)-amide;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-methanesulfonyl-pyrrolidin-3-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-pyrrolidin-3-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(1-methyl-1H-imidazole-4-sulfonyl)-pyrrolidin-3-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-pyrrolidin-3-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid ethylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid butylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid isopropylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (3-imidazol-1-yl-propyl)-amide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-pyrrolidin-1-yl-methanone;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid diethylamide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylamine;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-C-pyridin-4-yl-methanesulfonamide; and
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-2,2,2-trifluoro-acetamide.

### Claim 19 (depends on 1)

The compound of claim 1, said compound being selected from the group consisting of:
4-[4-(4-benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-piperidine-1-sulfonyl]-benzoic acid;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-dichloro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-fluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-2-yl-methanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-2-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-methanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-ethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(butane-1-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-3-ylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(pyridin-4-ylmethanesulfonyl)-piperidin-4-yl]-3-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(3,5-difluoro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(thiophene-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(1-methyl-1H-imidazole-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(5-methyl-isoxazole-4-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-C-phenyl-methanesulfonamide;
butane-1-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-C-pyridin-2-yl-methanesulfonamide;
thiophene-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
1-methyl-1H-imidazole-4-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(thiophene-3-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-ethyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanol;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(propane-2-sulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonitrile;
2-[5-benzo[1,3]dioxol-5-yl-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-3H-imidazol-4-yl]-6-ethyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-C-pyridin-2-yl-methanesulfonamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[4-(1H-tetrazol-5-yl)-bicyclo[2.2.2]oct-1-yl ]-3H-imidazol-4-yl}-6-methyl-pyridine;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetamide;
thiophene-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
1-methyl-1H-imidazole-4-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
thiophene-3-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-amide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
methanesulfonic acid 4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl ester;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetonitrile;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetic acid;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-ylmethyl}-C-pyridin-2-yl-methanesulfonamide;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(2-nitro-phenylmethanesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
1-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-sulfonylmethyl}-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one;
2-{5-benzo[1,3]dioxol-5-yl-2-[1-(4-chloro-benzenesulfonyl)-piperidin-4-yl]-3H-imidazol-4-yl}-6-methyl-pyridine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methylamide;
2-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidine-1-sulfonylmethyl}-phenylamine;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid (1-methyl-5-methylsulfanyl-1H-[1,2,4]triazol-3-yl)-amide;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid dimethylamide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-(3-chloro-phenyl)-methanone;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-cyclopropyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methoxy-amide;
4-[5-benzo[1,3]dioxol-5-yl-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-carbamic acid benzyl ester;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydrazide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-acetamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-C-phenyl-methanesulfonamide;
butane-1-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-amide;
propane-2-sulfonic acid {4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-amide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexylmethyl}-C-pyridin-2-yl-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-cyclohexyl}-methanesulfonamide;
4-[5-(6-methyl-pyridin-2-yl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[5-(6-methyl-pyridin-2-yl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[4-(6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
4-[4-(6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octan-1-ol;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
4-[4-(6-cyclopropyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-sulfamide;
sulfamic acid 4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl ester;
{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-carbamic acid benzyl ester;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonyl}-methanesulfonamide;
N-{4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carbonyl}-benzenesulfonamide;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-acetamide;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid hydroxyamide;
4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-methanesulfonamide;
2,2,2-trifluoro-N-{4-[4-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]-cyclohexyl}-acetamide;
4-[5-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-4-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid amide;
N-{4-[5-(6-methyl-pyridin-2-yl)-4-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-methanesulfonamide;
N-{4-[5-(6-methyl-pyridin-2-yl)-4-quinoxalin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]oct-1-yl}-acetamide; and
4-[4-(5-fluoro-6-methyl-pyridin-2-yl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester.

### Claim 20 (depends on 1)

A pharmaceutical composition comprising a compound of claim 1, and a pharmaceutically acceptable carrier.

### Claim 21 (depends on 17)

A pharmaceutical composition comprising a compound of claim 17 and a pharmaceutically acceptable carrier.