# US 7,612,084 B2 · Amine derivatives for the treatment of asthma and COPD

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- Number: US 7,612,084 B2
- Document ID: US7612084B2
- Status: Granted
- Kind: B2
- Application number: 11/725,335
- Filed: 2007-03-19
- Published: 2007-11-15
- Granted: 2009-11-03
- Earliest claimed: 2006-03-20
- Assignees: Pfizer Inc.
- Inventors: Kim James; Lyn Howard Jones; David Anthony Price
- Web page: https://patentgrep.com/patent/US7612084B2

## CPC

- C07C 311/08: having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/06: Antiasthmatics
- A61P 11/08: Bronchodilators
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07C 215/54: linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C07C 217/48: the carbon skeleton being unsaturated and containing rings
- C07C 217/62: linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C07C 223/02: having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C 233/43: having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
- C07C 255/13: containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
- C07C 271/16: to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C07C 271/66: Y being a hetero atom
- C07D 215/26: Alcohols; Ethers thereof
- C07D 215/60: N-oxides
- C07F 7/1804: {Compounds having Si-O-C linkages (Si-O-acyl linkages C07F7/1896)}
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

## Claims

### Claim 1

5-[(1R)-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one, or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A pharmaceutical composition comprising an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 2)

A pharmaceutical composition according to claim 2, further comprising one or more pharmaceutically acceptable excipients and/or additives.

### Claim 4 (depends on 1)

A method of treating asthma or chronic obstructive pulmonary disease (COPD) in a mammal, said method comprising administering to said mammal in need thereof a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt or pharmaceutically acceptable quaternary ammonium salt of said compound.