# US 7,611,900 B2 · High throughput screening methods for lubricating oil compositions

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- Number: US 7,611,900 B2
- Document ID: US7611900B2
- Status: Granted
- Kind: B2
- Application number: 11/985,292
- Filed: 2007-11-14
- Published: 2008-03-20
- Granted: 2009-11-03
- Earliest claimed: 2004-02-13
- Assignees: Chevron Oronite Company LLC
- Inventors: Robert H. Wollenberg
- Web page: https://patentgrep.com/patent/US7611900B2

## CPC

- C40B 40/04: Libraries containing only organic compounds
- G01N 33/2888: {Lubricating oil characteristics, e.g. deterioration (lubricating properties G01N33/30)}
- C40B: COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES (in silico combinatorial libraries of nucleic acids, proteins or peptides G16B35/00; in silico combinatorial chemistry G16C20/60)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Method for determining deposit formation tendencies for a plurality of fluid samples of different compositions is provided. Each sample includes one or more lubricating oil compositions containing at least one or more base oils of lubricating viscosity and one or more lubricating oil additives. The methods can advantageously be optimized using combinatorial chemistry, in which a database of combinations of lubricating oil compositions are generated. As market conditions vary and/or product requirements or customer specifications change, conditions suitable for forming desired products can be identified with little or no downtime.

## Claims

### Claim 1

A high throughput method for screening lubricating oil composition samples, under program control, comprising the steps of:
(a) conducting molecular modeling of at least one base oil of lubricating viscosity and at least one lubricating oil additive to provide leading candidates of the at least one base oil of lubricating viscosity and at least one lubricating oil additive for combination to formulate a leading candidate lubricating oil composition sample for testing;
(b) containing a plurality of the leading candidate lubricating oil composition samples comprising (i) a major amount of the at least one leading base oil of lubricating viscosity candidate, and (ii) a minor amount of the at least one leading lubricating oil additive candidate in varying percentages in a plurality of test reservoirs;
(c) measuring deposit formation of each sample comprising heating the sample to a predetermined temperature in the presence of a substrate and determining the amount of deposits formed on the substrate after a predetermined period of time by determining the weight of the substrate containing deposits and comparing the determined weight with the weight of the substrate to provide deposit formation data for each sample; and,
(d) outputting the results of step (c).

### Claim 2 (depends on 1)

The method of claim 1, wherein the base oil is a natural or synthetic oil.

### Claim 3 (depends on 1)

The method of claim 1, wherein the at least one lubricating oil additive is selected from the group consisting of antioxidants, anti-wear agents, detergents, rust inhibitors, dehazing agents, demulsifying agents, metal deactivating agents, friction modifiers, pour point depressants, antifoaming agents, co-solvents, package compatibilisers, corrosion-inhibitors, ashless dispersants, dyes, extreme pressure agents and mixtures thereof.

### Claim 4 (depends on 1)

The method of claim 1, wherein the at least one lubricating oil additive is selected from the group consisting of antioxidants, detergents, ashless dispersants and mixtures thereof.

### Claim 5 (depends on 1)

The method of claim 1, wherein the substrate is a transparent material.

### Claim 6 (depends on 5)

The method of claim 5, wherein the step of determining the amount of deposits formed on the transparent substrate comprises determining the opacity or light scattering of the sample and comparing the determined opacity or light scattering with the opacity or light scattering of a reference sample.

### Claim 7 (depends on 6)

The method of claim 6, wherein the opacity of the sample is determined by measuring the intensity of light passed through a sample.

### Claim 8 (depends on 6)

The method of claim 6, wherein the plurality of samples are in a linear array and are sequentially moved to a measuring station between a light source and a photocell for individually measuring the deposit formation of each sample.

### Claim 9 (depends on 1)

The method of claim 1, wherein a robotic assembly selectively retrieves the samples from an array of samples and individually positions the samples in a testing station for determination of the deposit formation.

### Claim 10 (depends on 9)

The method of claim 9, wherein said robotic assembly is controlled by a computer.

### Claim 11 (depends on 1)

The method of claim 1, wherein the step of outputting comprises storing the result of step (c) on a data carrier.

### Claim 12 (depends on 1)

The method of claim 1, further comprising the step of using the result of step (c) as a basis for obtaining a result of further calculations.

### Claim 13 (depends on 1)

The method of claim 1, wherein the at least one lubricating oil additive further comprises a diluent oil to form an additive concentrate.

### Claim 14 (depends on 1)

The method of claim 1, wherein the lubricating oil composition samples have a volume of no more than about 10 ml.

### Claim 15

A system for screening lubricant performance, under program control, comprising:
a) a supply of a major amount of at least one base oil of lubricating viscosity;
b) a supply of a minor amount of at least one lubricating oil additive;
c) a plurality of test receptacles;
d) means for conducting molecular modeling of the at least one base oil of lubricating viscosity and the at least one lubricating oil additive to provide leading candidates of the at least one base oil of lubricating viscosity and at least one lubricating oil additive for combination to formulate a leading candidate lubricating oil composition for testing;
e) means for combining selected quantities of the major amount of the at least one leading base oil of lubricating viscosity candidate with selected quantities of the minor amount of the at least one leading lubricating oil additive candidate in the plurality of test receptacles to form a plurality of leading candidate lubricating oil composition samples in the plurality of test receptacles;
f) receptacle moving means for individually positioning the test receptacles in a testing station for measurement of deposit formation of the respective sample; and
g) means for measuring the deposit formation of each respective sample in the testing station comprising means for heating the sample to a predetermined temperature in the presence of a substrate and means for determining the amount of deposits formed on the substrate after a predetermined period of time by determining the weight of the substrate containing deposits and comparing the determined weight with the weight of the substrate to obtain deposit formation data associated with the sample and for transferring the deposit formation data to a computer controller.

### Claim 16 (depends on 15)

The system of claim 15, wherein the receptacle moving means comprises a movable carriage.

### Claim 17 (depends on 15)

The system of claim 15, wherein the receptacle moving means comprises a robotic assembly having a movable arm for grasping and moving a selected individual receptacle.

### Claim 18 (depends on 15)

The system of claim 15, wherein the receptacle moving means comprises means for agitating the test receptacles.

### Claim 19 (depends on 15)

The system of claim 15, wherein each test receptacle has a bar code affixed to an outer surface thereof.

### Claim 20 (depends on 19)

The system of claim 19, further comprising a bar code reader.

### Claim 21 (depends on 15)

The system of claim 15, wherein the base oil of lubricating viscosity is a natural or synthetic oil.

### Claim 22 (depends on 15)

The system of claim 15, wherein the at least one lubricating oil additive is selected from the group consisting of antioxidants, anti-wear agents, detergents, rust inhibitors, dehazing agents, demulsifying agents, metal deactivating agents, friction modifiers, pour point depressants, antifoaming agents, co-solvents, package compatibilisers, corrosion-inhibitors, ashless dispersants, dyes, extreme pressure agents and mixtures thereof.

### Claim 23 (depends on 15)

The system of claim 15, wherein the at least one lubricating oil additive is selected from the group consisting of antioxidants, detergents, ashless dispersants and mixtures thereof.