# US 7,611,892 B2 · Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods

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- Number: US 7,611,892 B2
- Document ID: US7611892B2
- Status: Granted
- Kind: B2
- Application number: 11/453,608
- Filed: 2006-06-15
- Published: 2007-01-18
- Granted: 2009-11-03
- Earliest claimed: 2000-03-24
- Assignees: President and Fellows of Harvard College
- Inventors: Fahri Saatcioglu
- Web page: https://patentgrep.com/patent/US7611892B2

## CPC

- C07K 14/705: Receptors; Cell surface antigens; Cell surface determinants {(tumour specific antigens C07K14/4748)}
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The invention provides novel STAMP2 nucleic acid molecules, polypeptides, antibodies, and modulatory compounds for use in methods of diagnosing, treating, and preventing diseases and conditions of the prostate and testis, such as cancer.

## Claims

### Claim 1

A substantially pure polynucleotide sequence that comprises the STAMP2 nucleic acid sequence as set forth in SEQ ID NO: 33, or the fully complementary sequence thereof.

### Claim 2 (depends on 1)

The substantially pure polynucleotide of claim 1, wherein said polynucleotide consists of the nucleic acid sequence of SEQ ID NO: 33, or the fully complementary sequence thereof.

### Claim 3

A substantially pure polynucleotide comprising a sequence encoding a polypeptide that comprises the amino acid sequence of SEQ ID NO: 34, or the fully complementary sequence of said polynucleotide.

### Claim 4 (depends on 3)

The substantially pure polynucleotide of claim 3, comprising a sequence encoding a polypeptide that consists of the amino acid sequence of SEQ ID NO: 34, or the fully complementary sequence of said polynucleotide.

### Claim 5 (depends on 3)

The substantially pure polynucleotide of claim 3, wherein said polynucleotide comprises a sequence identical or fully complementary to at least 8 consecutive nucleotides of nucleotides 107-167 or nucleotides 1306-1360 of SEQ ID NO: 33.

### Claim 6 (depends on 1)

A vector comprising the polynucleotide of claim 1, wherein said polynucleotide is positioned for expression.

### Claim 7 (depends on 3)

A vector comprising the polynucleotide of claim 3, wherein said polynucleotide is positioned for expression.