# US 7,611,843 B2 · Eubacterial tmRNA sequences and uses thereof

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- Number: US 7,611,843 B2
- Document ID: US7611843B2
- Status: Granted
- Kind: B2
- Application number: 11/329,230
- Filed: 2006-01-11
- Published: 2006-09-28
- Granted: 2009-11-03
- Earliest claimed: 1999-04-07
- Assignees: University of Utah Research Foundation
- Inventors: Brice Felden
- Web page: https://patentgrep.com/patent/US7611843B2

## CPC

- C12Q 1/689: for bacteria
- C12Q 2600/136: Screening for pharmacological compounds
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays.

## Claims

### Claim 1

An isolated nucleic acid sequence selected from the group consisting of the tmRNA sequence for Staphylococcus aureus set forth in SEQ ID NO:86, and the coding sequence thereof consisting of nucleotides 94-129 of SEQ ID NO:86.

### Claim 2

A method for diagnosing a bacterial infectious agent comprising determining the presence of a bacterial nucleic acid sequence selected from the group consisting of the tmRNA sequence for Staphylococcus aureus set forth in SEQ ID NO: NO:86, and the coding sequence thereof consisting of nucleotides 94-129 of SEQ ID NO:86.

### Claim 3 (depends on 2)

The method of claim 2, wherein the determination is made by performing an amplification-based assay.