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US 7,611,839 B2Granted
Methods for diagnosing RCC and other solid tumors
AssigneeWyeth
InventorsNatalie C. Twine, Michael E. Burczynski, William L. Trepicchio, Andrew J. Dorner, Jennifer A. Stover, Donna K. Slonim
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Abstract
Methods, systems and equipment for diagnosing renal cell carcinoma (RCC) and other solid tumors. This invention identifies numerous disease genes that are differentially expressed in the peripheral blood of patients having RCC or other solid tumors relative to disease-free humans. These disease genes can be used as surrogate markers for detecting the presence or absence of RCC or other solid tumors.
Claims7
A method for confirming a diagnosis of renal cell carcinoma (RCC) in a human, the method comprising the steps of:
- a) providing at least one peripheral blood sample of a human;
- b) generating an expression profile comprising expression levels of two RCC disease genes in said at least one peripheral blood sample of the human;
- c) comparing the expression profile generated in step b) to at least one reference expression profile comprising expression levels of said two RCC disease genes wherein the reference expression profile is obtained from peripheral blood samples from patients having RCC or peripheral blood samples from disease-free humans, wherein said comparison is used to indicate the presence or absence of RCC in the human;
- and
- wherein (i) the human has a prior diagnosis of RCC and (ii) said two RCC disease genes are eukaryotic elongation factor 1 alpha 2 (EEF1A2, SEQ ID NO:285) and toll-like receptor 2 (TLR2, SEQ ID NO:1).
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Dependencies are inferred from the claim text.