# US 7,611,782 B2 · Titanium oxide complex and production method thereof, and medical material using the same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,611,782 B2 - Document ID: US7611782B2 - Status: Granted - Kind: B2 - Application number: 10/510,132 - Filed: 2003-12-12 - Published: 2005-10-13 - Granted: 2009-11-03 - Earliest claimed: 2003-08-26 - Assignees: Japan AS Represented By President of National Cardiovascular Center - Inventors: Tsutomu Furuzono; Akio Kishida - Web page: https://patentgrep.com/patent/US7611782B2 ## CPC - C08J 7/12: Chemical modification - A61L 27/06: Titanium or titanium alloys - A61L 27/446: {with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46} - A61L 31/022: {Metals or alloys} - A61L 31/128: {containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127} - C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract A reactive functional group is introduced into titanium oxide, and an active group which is capable of reacting with the reactive functional group is introduced into a polymer-based material, and the reactive functional group and the active group are reacted with each other, thereby producing a titanium oxide complex in which the polymer-based material and the titanium oxide chemically bond to each other. Further, a functional group of the polymer-based material and the titanium oxide are reacted with each other, thereby producing the titanium oxide complex without performing chemical pretreatment with respect to the titanium oxide. ## Claims ### Claim 1 A polymer-based material chemically bonded to titanium oxide, comprising: the polymer-based material having an active group; and the titanium oxide having an amino group which is capable of reacting with the active group, wherein the active group and the amino group are bonded directly to each other based on an amido bond and wherein said titanium oxide is chemically bonded to said polymer-based material. ### Claim 2 (depends on 1) The polymer-based material chemically bonded to titanium oxide as set forth in claim 1, wherein the polymer-based material is silicone rubber. ### Claim 3 (depends on 1) The polymer-based material chemically bonded to titanium oxide as set forth in claim 1, wherein the titanium oxide having the reactive functional group which is capable of reacting with the active group has a photocatalyst property. ### Claim 4 (depends on 1) A medical material, comprising the polymer-based material chemically bonded to titanium oxide as set forth in claim 1. ### Claim 5 (depends on 1) A method of producing a titanium oxide bonded to a polymer based material, comprising: an active group introduction step of introducing an active group into the polymer-based material as in claim 1; a reactive functional group introduction step of introducing a reactive functional group, which is capable of reacting with the active group, into the titanium oxide; and a reaction step of reacting the active group with the reactive functional group. ### Claim 6 (depends on 5) The method as set forth in claim 5, wherein a silane coupling agent having the reactive functional group is used in the reactive functional group introduction step. ### Claim 7 (depends on 5) The method as set forth in claim 5, wherein the active group is a carboxyl group, and the reactive functional group is an amino group. ### Claim 8 (depends on 5) The method as set forth in claim 5, wherein the polymer-based material is a medical polymer material. ### Claim 9 A titanium oxide bonded to a polymer based material, comprising: a hydroxyl group contained in the titanium oxide; and the polymer-based material having an alkoxysilyl group which is capable of chemically bonding to the hydroxyl group, wherein the hydroxyl group and the polymer-based material are bonded directly to each other based on a chemical bond and wherein said titanium oxide is chemically bonded to said polymer-based material. ### Claim 10 (depends on 9) The titanium oxide bonded to a polymer based material as set forth in claim 9, wherein the polymer-based material is silkfibroin. ### Claim 11 (depends on 9) A medical material, comprising the titanium oxide bonded to a polymer based material as set forth in claim 9. ### Claim 12 (depends on 6) A method of producing a titanium oxide bonded to a polymer-based material as in claim 6, comprising: an introduction step of introducing a functional group, which is capable of chemically bonding to a hydroxyl group contained in the titanium oxide, into the polymer-based material; and a functional group reaction step of reacting the functional group of the polymer-based material with the hydroxyl group contained in the titanium oxide. ### Claim 13 (depends on 12) The method as set forth in claim 12, wherein the functional group is at least one kind selected from a group of an alcoxysilyl group and an isocyanate group. ### Claim 14 (depends on 12) The method as set forth in claim 12, wherein a silane coupling agent having the functional group is used in the introduction step. ### Claim 15 (depends on 12) The method as set forth in claim 12, wherein the polymer-based material is a medical polymer material.