# US 7,611,739 B2 · Method of using guava extract and composition including guava extract

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- Number: US 7,611,739 B2
- Document ID: US7611739B2
- Status: Granted
- Kind: B2
- Application number: 11/327,586
- Filed: 2006-01-06
- Published: 2007-07-12
- Granted: 2009-11-03
- Earliest claimed: 2006-01-06
- Assignees: Amerilab Technologies, Inc.
- Inventors: Fred Wehling; Mary Aldritt; GeMing Lui
- Web page: https://patentgrep.com/patent/US7611739B2

## CPC

- A61K 36/61: Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
- A23L 2/40: Effervescence-generating compositions
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 9/0007: {Effervescent (A61K9/0065 takes precedence)}
- A61K 9/0058: {Chewing gums (non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00)}
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61P 25/32: Alcohol-abuse
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 39/02: Antidotes
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method of using guava extract is disclosed that includes administering alcohol to a mammal, and administering guava extract within no greater than about 12 hours of administering of the alcohol. A composition is also disclosed that includes a pharmaceutically acceptable carrier and guava extract.

## Claims

### Claim 1

A composition comprising:
at least 500 mg of guava extract selected from the group consisting of a water extract of guava, a boiling water extract of guava, an organic solvent extract of guava, an oil extract of guava, and combinations thereof; and
a pharmaceutically acceptable carrier comprising an effervescent agent comprising an acid and a base comprising sodium bicarbonate, sodium carbonate, sodium sesquicarbonate or a combination thereof,
said composition being in the form of an oral dosage form and having the effect of alleviating at least one of headache, nausea, dry mouth, lack of appetite, shakiness, and fatigue in a human.

### Claim 2 (depends on 1)

The composition of claim 1, wherein said guava extract comprises a water extract of guava leaves.

### Claim 3 (depends on 1)

The composition of claim 1, wherein said guava extract comprises at least one of an organic solvent extract of guava leaves and an oil extract of guava leaves.

### Claim 4 (depends on 1)

The composition of claim 1, wherein said guava extract comprises a boiling water extract of guava leaves.

### Claim 5 (depends on 1)

The composition of claim 1, wherein said carrier further comprises water, oil, binder, lubricant, or a combination thereof.

### Claim 6 (depends on 1)

The oral dosage form of claim 1, wherein said oral dosage form is in the form of a powder, liquid, tablet, pill, capsule, gel cap, a chewing gum or a combination thereof.

### Claim 7 (depends on 1)

The oral dosage form of claim 1, wherein said oral dosage form is in the form of a suspension, a solution, an emulsion, a syrup or a combination thereof.

### Claim 8 (depends on 1)

A powder comprising the composition of claim 1.

### Claim 9 (depends on 1)

A tablet comprising the composition of claim 1, said carrier further comprising
from 10% by weight to about 60% by weight binder; and
from 1% by weight to about 15% by weight lubricant.

### Claim 10

A solid effervescent composition comprising:
at least 500 mg of guava extract selected from the group consisting of a water extract of guava, a boiling water extract of guava, an organic solvent extract of guava, an oil extract of guava, and combinations thereof; and
an effervescent agent comprising an acid and a base comprising sodium bicarbonate, sodium carbonate, sodium sesquicarbonate or a combination thereof,
said composition being an oral dosage form in the form of a tablet or a powder and having the effect of alleviating at least one of headache, nausea, dry mouth, lack of appetite, shakiness, and fatigue in a human.

### Claim 11 (depends on 10)

The effervescent composition of claim 10, comprising at least about 1000 mg said guava extract.

### Claim 12 (depends on 10)

The effervescent composition of claim 10, wherein said guava extract is obtained through an extraction at least one of leaves and stems of a guava plant.

### Claim 13 (depends on 10)

The effervescent composition of claim 10, further comprising no greater than 400 mg flavor agent.

### Claim 14

An article comprising:
a moisture-proof package; and
an oral dosage form comprising an effervescent composition disposed within the moisture-proof package, said composition comprising
at least 500 mg of guava extract selected from the group consisting of a water extract of guava, a boiling water extract of guava, an organic solvent extract of guava, an oil soluble extract of guava, and combinations thereof, and
a pharmaceutically acceptable carrier comprising an effervescent agent comprising an acid and a base comprising sodium bicarbonate, sodium carbonate, sodium sesquicarbonate or a combination thereof, said composition having the effect of alleviating at least one of headache, nausea, dry mouth, lack of appetite, shakiness, and fatigue in a human.

### Claim 15 (depends on 14)

The article of claim 14, wherein the moisture-proof package is selected from the group consisting of a sealed metal foil pouch, blister pack and desiccant capped tube.

### Claim 16 (depends on 14)

The article of claim 14, wherein said composition comprises at least about 1000 mg guava extract.

### Claim 17

A solid effervescent composition comprising:
at least 500 mg guava extract, said extract being obtained from the root of a guava plant; and
an effervescent agent comprising an acid and a base,
said composition being in the form of a tablet or a powder.
