# US 7,611,715 B2 · Agaricus extract for preventing the induction or metastasis of cancer

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- Number: US 7,611,715 B2
- Document ID: US7611715B2
- Status: Granted
- Kind: B2
- Application number: 11/737,709
- Filed: 2007-04-19
- Published: 2007-08-09
- Granted: 2009-11-03
- Earliest claimed: 2002-07-02
- Assignees: SSI Corporation
- Inventors: Insu Peter Lee; Tomihisa Ota
- Web page: https://patentgrep.com/patent/US7611715B2

## CPC

- A61K 36/071: {Agaricus}
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 35/00: Antineoplastic agents
- A61P 35/04: specific for metastasis
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A foodstuff capable of preventing the induction or metastasis of cancer is provided. In particular, an Agaricus blazei Murill extract comprising an ingredient capable of preventing the induction or metastasis of cancer is provided. The ingredient can be a chromatographic main elute fraction of 100 to 2000 molecular weight, obtained by the steps of extracting the fruit body of Agaricus blazei Murill with hot water, dialyzing the resultant extract, and subjecting the thus obtained dialysis external fluid to chromatography. Alternatively, the ingredient can be a dialysis external fluid obtained by the steps of extracting the fruit body of Agaricus blazeiMurill with hot water, adding ethanol to the resultant extract to thereby obtain precipitates, dissolving the precipitates in water, and dialyzing the solution.

## Claims

### Claim 1

A method for inhibiting induction of a cancer, metastasis of a cancer, or both, wherein the cancer is selected from lung or large intestine cancer, and wherein said cancer is caused by a carcinogen, said method comprising
administering a pharmacologically effective amount of extract from agaricus, wherein the extract is a chromatographic elute fraction of 100 to 2000 molecular weight obtained by the steps of extracting the fruit body of agaricus with water, dialyzing the resultant extract, and subjecting the thus obtained dialysis external fluid to chromatography.

### Claim 2

A method for inhibiting induction of a cancer, metastasis of a cancer, or both, wherein the cancer is selected from lung or large intestine cancer, and wherein said cancer is caused by a carcinogen, said method comprising
administering a pharmacologically effective amount of extract from agaricus, wherein the extract is a dialysis external fluid obtained by the steps of extracting the fruit body of agaricus with water, adding ethanol to the resultant extract to thereby obtain precipitates, dissolving the precipitates in water, and dialyzing the solution.

### Claim 3 (depends on 1, 2)

The method according to claim 1 or claim 2, wherein the cancer is induced by urethane (ethyl carbamate), NNK ((4-N-methyl-N-nitroamino)-1-(3-pyridyl)-1-buthanone) or azoxymethane.

### Claim 4

A method for inhibiting metastasis of large intestine cancer wherein the cancer is caused by a carcinogen, said method comprising
administering a pharmacologically effective amount of extract from agaricus.

### Claim 5 (depends on 4)

The method according to claim 4, wherein the cancer is induced by urethane (ethyl carbamate), NNK ((4-N-methyl-N-nitroamino)-1-(3-pyridyl)-1-buthanone) or azoxymethane.