# US 7,611,703 B1 · Kidney disease targets and uses thereof

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- Number: US 7,611,703 B1
- Document ID: US7611703B1
- Status: Granted
- Kind: B1
- Application number: 11/717,149
- Filed: 2007-03-13
- Granted: 2009-11-03
- Earliest claimed: 2006-03-13
- Assignees: Celera Corporation
- Inventors: Elizabeth G. Joseloff; Yeoun Jin Kim; Tao He; Steve Ruben
- Web page: https://patentgrep.com/patent/US7611703B1

## CPC

- C07K 14/4748: {Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE}
- C07K 16/3038: {Kidney, bladder}
- A61K 2039/505: {comprising antibodies}
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.

## Claims

### Claim 1

A method of diagnosing kidney cancer in a subject suspected of having kidney cancer, the method comprising detecting a level of LAMP1 protein in a sample from the subject, wherein a higher level of LAMP1 protein in said sample as compared to the level of LAMP1 protein in normal samples indicates that said subject has kidney cancer.

### Claim 2 (depends on 1)

The method of claim 1, wherein the amino acid sequence of the LAMP1 protein comprises a sequence selected from the group consisting of SEQ ID NOS: 1-3.

### Claim 3 (depends on 1)

The method of claim 1, wherein the amino acid sequence of the LAMP1 protein consists of a sequence selected from the group consisting of SEQ ID NOS: 1-3.

### Claim 4 (depends on 1)

The method of claim 1, wherein the LAMP1 protein is detected by contacting the sample with an isolated antibody that selectively binds to the LAMP1 protein and detecting binding of the antibody to the LAMP1 protein.

### Claim 5 (depends on 4)

The method of claim 4, wherein the antibody is coupled to a detectable substance.