# US 7,611,078 B2 · Method of producing powered medicine multi-dose administering device and apparatus thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,611,078 B2 - Document ID: US7611078B2 - Status: Granted - Kind: B2 - Application number: 10/489,662 - Filed: 2004-03-16 - Published: 2004-12-02 - Granted: 2009-11-03 - Earliest claimed: 2002-07-16 - Assignees: Teijin Limited - Inventors: Yasuhiro Zaima; Masahiko Dohi; Seiji Mochizuki; Hiroshi Kuroda - Web page: https://patentgrep.com/patent/US7611078B2 ## CPC - G01G 17/00: Apparatus for or methods of weighing material of special form or property (determining weight by measuring volume G01F) - A61M 15/0066: {with means for varying the dose size} - A61M 2202/064: Powder - Y10T 29/49826: Assembling or joining - G01G: WEIGHING (sorting by weighing B07C5/16) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION ## Abstract Parts of a powdered medicine multi-dose administering device are assembled, powdered medicine is filled and assembly that is obtained is inspected all on an automatic production line to increase productivity while preventing the production of defective products. The powdered medicine multi-dose administering device is produced through automated steps of inserting a filter (12) in a filter-fitting portion (11a) of a container (10), inserting an inner cylinder (15) in the container body (10), filling the container with the powdered medicine through a ring-like opening between an opening in the upper part of the container and the inner cylinder, fitting an inner closure (19) to the container and to the inner cylinder, fitting a nozzle (20) to the container while coupling it to the inner cylinder, and inspecting the thus obtained assembly. ## Claims ### Claim 1 A method of producing a powdered medicine multi-dose administering device which includes a container (10) capable of storing a multi-dose amount of powdered medicine and having, in the bottom portion thereof, a hole (10a) for containing a single-dose amount of the medicine and a first filter-fitting portion (11a), a first filter (12) fitted into the first filter-fitting portion, a second hole (10b) and a second filter-fitting portion (11b) provided in the bottom portion of the container, a second filter (13) coarser than the first filter (12) being fitted to the second filter-fitting portion, an inner cylinder (15) capable of being rotated between a filling position and an administering position while maintaining contact with the inner bottom surface of the container, an inner closure (19) having a center hole for rotatably supporting an upper part of the inner cylinder and for closing an opening at the upper end of the container being fitted to the inner periphery of the opening at the upper part of the container, and a nozzle (20) coupled to the upper end of the inner cylinder so as to transmit the rotation, rotatably fitted to the outer periphery of the opening at the upper part of the container and having a medicine discharge passage (20a), wherein, at the filling position, the powdered medicine in the container is supplied to the medicine-containing hole (10a) through an opening (17) in the inner cylinder and the second filter and the second hole are communicated with the medicine passage (18) in the inner cylinder and, at the administering position, the air is blown into the medicine-containing hole (10a) through the first filter, so that the medicine in the medicine-containing hole is discharged to the exterior through a medicine passage (18) of the inner cylinder and the medicine discharge passage (20a) of the nozzle; said method of producing a powdered medicine multi-dose administering device comprising the steps of: inserting the second filter (13) in the second filter-fitting portion (11b); inserting the first filter (12) in the first filter-fitting portion (11a); inserting the inner cylinder (15) in the container body (10); filling the container with the powdered medicine; inserting the inner closure (19) to the container and fitting it to the inner cylinder; and fitting the nozzle (20) to the container to couple it to the inner cylinder. ### Claim 2 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, in the step of inserting the first and second filters (11, 12), the container (10) is installed with its bottom portion facing upward. ### Claim 3 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein in the step of inserting the first and second filters (12, 13), the insertion is conducted while applying insertion guides to the first and second filter-fitting portions (11a, 11b), respectively. ### Claim 4 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, at the time of inserting the first filter (12) in the first filter-fitting portion (11a), the up-and-down direction of the filter is confirmed; while at the time of inserting the second filter (13) in the second filter-fitting portion (11b), the up-and-down direction of the filter is not confirmed. ### Claim 5 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein in inserting the first filter (12) in the first filter-fitting portion (11a), the first filter is provisionally inserted in a first step and is, then, press-inserted in a next step. ### Claim 6 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein the second filter (13) is inserted in the second filter-fitting portion (11b), then the depth of insertion of the second filter is measured and the first filter (12) is press-inserted in the first filter-fitting portion (11a), then the depth of press-insertion of the first filter (12) is measured. ### Claim 7 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein after the first and second filters (12, 13) have been inserted in the first and second filter-fitting portions (11a, 11b), the container (10) is turned upside down. ### Claim 8 (depends on 7) A method of producing a powdered medicine multi-dose administering device according to claim 7, wherein the steps of inserting the first and second filters (12, 13) are executed while the container (10) is being conveyed by a first conveyer, and the steps after the container (10) is turned upside down are executed while the container (10) is being conveyed by a second conveyer. ### Claim 9 (depends on 8) A method of producing a powdered medicine multi-dose administering device according to claim 8, wherein in transferring the container (10) onto the first conveyer, the position of the container (10) in the rotational direction is determined by utilizing a protrusion (14) provided at a central position on the inner bottom surface of the container. ### Claim 10 (depends on 8) A method of producing a powdered medicine multi-dose administering device according to claim 8, wherein, in transferring the container (10) onto the second conveyer, the position of the container (10) in the rotational direction is determined by utilizing the first and second filter-fitting portions (11a, 11b) that are protruding outward from the bottom portion of the container (10). ### Claim 11 (depends on 8) A method of producing a powdered medicine multi-dose administering device according to claim 8, wherein after the container (10) is transferred onto the second conveyer, the interior of the container is cleaned by injecting the compressed air into the container and sucking the air prior to inserting the inner cylinder (15) in the container. ### Claim 12 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, in inserting the inner cylinder (15) in the container, the position of the inner cylinder in the rotational direction is determined by utilizing a non-circular portion formed at a portion coupled to the nozzle at the upper end of the inner cylinder (15). ### Claim 13 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein after the inner cylinder (15) is inserted in the container, the depth of insertion of the inner cylinder is measured. ### Claim 14 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, after the inner cylinder (15) is inserted in the container, the container is cleaned by supplying air therein while holding the interior of the container by the inner cylinder. ### Claim 15 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, in the step of filling the container with the powdered medicine, the container is filled with the powdered medicine through a ring-like opening between the opening at the upper end of the container and the inner cylinder (15) by utilizing a filling funnel. ### Claim 16 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, in the step of filling the container with the powdered medicine, the container is vibrated. ### Claim 17 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, in the step of inserting the inner closure (19) in the container, the inner closure is fixedly fitted to the inner periphery of the opening at the upper part of the container and, at the same time, the rotary shaft portion (15d) at the upper part of the inner cylinder is fitted to the center hole of the inner closure in a non-fixed manner. ### Claim 18 (depends on 17) A method of producing a powdered medicine multi-dose administering device according to claim 17, wherein, in the step of inserting the inner closure (19) in the container, the inner closure is provisionally inserted in the container in a first step and, then, is press-inserted in the container in a next step. ### Claim 19 (depends on 18) A method of producing a powdered medicine multi-dose administering device according to claim 18, wherein, in press-inserting the inner closure 19 in the container, the inner closure is press-inserted in the container while holding the upper end of the inner cylinder (15) that is protruded upward beyond the inner closure. ### Claim 20 (depends on 18) A method of producing a powdered medicine multi-dose administering device according to claim 18, wherein, in holding the upper end of the inner cylinder (15), the position of the inner cylinder is corrected at the same time by utilizing the noncircular shaft portion (15c) at the upper end of the inner cylinder. ### Claim 21 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, after the inner closure (19) is fitted into the container and to the inner cylinder, the depth of insertion of the inner closure is measured. ### Claim 22 (depends on 20) A method of producing a powdered medicine multi-dose administering device according to claim 20, wherein, in the step of inserting the nozzle (20) in the container, the nozzle is fitted in a non-fixed manner to the outer periphery of the opening at the upper part of the container body and, at the same time, a non-circular hole (20c) of the nozzle is coupled to the noncircular shaft portion (15c) at the upper end of the inner cylinder in a manner to transmit rotation. ### Claim 23 (depends on 22) A method of producing a powdered medicine multi-dose administering device according to claim 22, wherein, in the step of inserting the nozzle (20) in the container, a pin is inserted in the noncircular hole (20c) of the nozzle that corresponds to the noncircular portion at the upper end of the inner cylinder (15) prior to inserting the nozzle, thereby to determine the position of the nozzle in the direction of rotation. ### Claim 24 (depends on 1) A method of producing a powdered medicine multi-dose administering device according to claim 1, wherein, after the nozzle (20) is inserted in the container, the depth of insertion of the nozzle is measured. ### Claim 25 A method of assembling a powdered medicine administering device which permits an inner cylinder to move between a medicine filling position and a blow-out position upon turning a nozzle, comprising the steps of: incorporating first and second filters (12, 13) on the outer side of a bottom portion of a container (10) with the bottom portion being positioned on the upper side, the second filter (13) being coarser than the first filter (12); turning the container upside-down so that the open end of the container faces upward; inserting the inner cylinder (15) in the container from the side of open end of the container; filling the container with a predetermined amount of powdered medicine from the side of open end of the container; securing and fitting the inner closure (19) to the open end of the container as well as to the inner cylinder so that the inner cylinder partly protrudes toward outside of the container; and rotatably fitting the nozzle (20) to the open end of the container while coupling it to the inner closure (19) in a manner to transmit the rotation. ### Claim 26 A method of producing a powdered medicine multi-dose administering device which includes a container (10) capable of storing a multi-dose amount of powdered medicine and having, in the bottom portion thereof, a hole (10a) for containing a single-dose amount of the medicine and a first filter-fitting portion (11a), a first filter (12) fitted into the first filter-fitting portion, a second hole (10b) and a second filter-fitting portion (11b) provided in the bottom portion of the container, a second filter (13) coarser than the first filter (12) being fitted to the second filter-fitting portion, an inner cylinder (15) capable of being rotated between a filling position and an administering position while maintaining contact with the inner bottom surface of the container, an inner closure (19) having a center hole for rotatably supporting an upper part of the inner cylinder and for closing an opening at the upper end of the container being fitted to the inner periphery of the opening at the upper part of the container, and a nozzle (20) coupled to the upper end of the inner cylinder so as to transmit the rotation, rotatably fitted to the outer periphery of the opening at the upper part of the container and having a medicine discharge passage (20a), wherein, at the filling position, the powdered medicine in the container is supplied to the medicine-containing hole (10a) through an opening (17) in the inner cylinder and the second filter and the second hole are communicated with the medicine passage (18) in the inner cylinder and, at the administering position, air is blown into the medicine-containing hole (10a) through the first filter, so that the medicine in the medicine-containing hole is discharged to the exterior through the medicine passage (18) of the inner cylinder and the medicine discharge passage (20a) of the nozzle, said method of producing a powdered medicine multi-dose administering device comprising the steps of: inserting the second filter (13) in the second filter-fitting portion (11b); inserting the first filter (12) in the first filter-fitting portion (11a); inserting the inner cylinder (15) in the container body (10); filling the container with the powdered medicine; inserting the inner closure (19) to the container and fitting it to the inner cylinder; fitting the nozzle (20) to the container to couple it to the inner cylinder; and inspecting the thus obtained assembly. ### Claim 27 (depends on 26) A method of producing a powdered medicine multi-dose administering device according to claim 26, wherein in a state where the assembly is obtained, the inner cylinder (15) is set at the administering position, and the step of inspecting the assembly comprises the following sub-steps of: first measuring sub-step of measuring the initial load of the assembly; turning the nozzle (20) by a predetermined angle relative to the container body to bring the inner cylinder to the filling position; vibrating the assembly; turning the nozzle in the opposite direction by a predetermined angle relative to the container body to bring the inner cylinder to the administering position; sucking the air from the end of the nozzle (20) while injecting the compressed air through the filter so that a single-dose amount of the powdered medicine in the medicine-containing hole (10a) is injected from the nozzle; and second measuring sub-step of measuring the load of the assembly after the injection and calculating the amount of injection from the weight difference between before and after the injection; and wherein said first and second measuring sub-steps are carried out by an electronic balance provided with a windbreak. ### Claim 28 (depends on 27) A method of producing a powdered medicine multi-dose administering device according to claim 27, wherein, after the initial load of the assembly is measured, the assembly is transferred onto an index table, and the individual sub-steps in the step of inspection are executed while an index table is being turned. ### Claim 29 (depends on 27) A method of producing a powdered medicine multi-dose administering device according to claim 27, wherein a rotary cylinder is used in the foregoing two sub-steps of turning the nozzle relative to the container body, and an urethane rubber is arranged at the chuck portion of the rotary cylinder that comes into contact with the nozzle. ### Claim 30 An apparatus for producing a powdered medicine multi-dose administering device which includes a container (10) capable of storing a multi-dose amount of powdered medicine and having, in the bottom portion thereof, a hole (10a) for containing a single-dose amount of the medicine and a first filter-fitting portion (11a), a first filter (12) fitted into the first filter-fitting portion, a second hole (10b) and a second filter-fitting portion (11b) provided in the bottom portion of the container, a second filter (13) coarser than the first filter (12) being fitted to the second filter-fitting portion, an inner cylinder (15) capable of being rotated between a filling position and an administering position while maintaining contact with the inner bottom surface of the container, an inner closure (19) having a center hole for rotatably supporting an upper part of the inner cylinder and for closing an opening at the upper end of the container being fitted to the inner periphery of the opening at the upper part of the container, and a nozzle (20) coupled to the upper end of the inner cylinder so as to transmit the rotation, rotatably fitted to the outer periphery of the opening at the upper part of the container and having a medicine blow-out passage (20a), wherein, at the filling position, the powdered medicine in the container is supplied to the medicine-containing hole (10a) through an opening (17) in the inner cylinder and the second filter and the second hole are communicated with the medicine passage (18) in the inner cylinder, and, at the administering position, the air is blown into the medicine-containing hole (10a) through the filter, so that the medicine in the medicine-containing hole is discharged to the exterior through the medicine passage (18) of the inner cylinder and the medicine discharge passage (20a) of the nozzle, said an apparatus for automatically producing a powdered medicine multi-dose administering device, comprising: a production unit for inserting the first filters in the first filter-fitting portions, inserting the second filter (13) in the second filter-fitting portion (11b); inserting the inner cylinder in the container body, filling the container with the powdered medicine, fitting the inner closure to the container and to the inner cylinder, and fitting the nozzle (20) to the container while coupling it to the inner cylinder to produce an assembly; and an inspection unit for inspecting the assembly that is produced and for measuring the amount of injection of a single-dose amount of the powdered medicine. ### Claim 31 A powdered medicine multi-dose administering device which includes: a container (10) capable of storing a multi-dose amount of powdered medicine and having, in the bottom portion thereof, a first hole (10a) for containing a single-dose amount of the medicine and a filter-fitting portion (11a); a first filter (12) fitted into the filter-fitting portion, an inner cylinder (15) capable of being rotated between a filling position and an administering position while maintaining contact with the inner bottom surface of the container; an inner closure (19) having a center hole for rotatably supporting an upper part of the inner cylinder and for closing an opening at the upper end of the container being fitted to the inner periphery of the opening at the upper part of the container; a nozzle (20) coupled to the upper end of the inner cylinder so as to transmit the rotation, rotatably fitted to the outer periphery of the opening at the upper part of the container and having a medicine discharge passage (20a); a pump (21) capable of blowing air into the first hole (10a) through the first filter (12); wherein, at the filling position, the powdered medicine in the container is supplied to the medicine-containing hole (10a) through an opening (17) in the inner cylinder, and, at the administering position, the air is blown into the medicine-containing hole (10a) through the first filter, so that the medicine in the medicine-containing hole is discharged to the exterior through a medicine passage (18) of the inner cylinder and the medicine discharge passage (20a) of the nozzle; and wherein a second hole (10b) and a second filter-fitting portion (11b) are provided in the bottom portion of the container, a second filter (13) coarser than the first filter (12) is fitted to the second filter-fitting portion, and the second filter and the second hole are communicated with the medicine passage (18) in the inner cylinder at the filling position. ### Claim 32 An assembly of a powdered medicine multi-dose administering device which includes: a container body (10) capable of storing a multi-dose amount of powdered medicine and having, in the bottom portion thereof, a first hole (10a) for containing a single-dose amount of the medicine and a filter-fitting portion (11a); a first filter (12) fitted into the filter-fitting portion, an inner cylinder (15) capable of being rotated between a filling position and an administering position while maintaining contact with the inner bottom surface of the container; an inner closure (19) having a center hole for rotatably supporting an upper part of the inner cylinder and for closing an opening at the upper end of the container being fitted to the inner periphery of the opening at the upper part of the container; a nozzle (20) coupled to the upper end of the inner cylinder so as to transmit the rotation, rotatably fitted to the outer periphery of the opening at the upper part of the container and having a medicine discharge passage (20a); wherein, at the filling position, the powdered medicine in the container is supplied to the medicine-containing hole (10a) through an opening (17) in the inner cylinder, and, at the administering position, air is blown into the medicine-containing hole (10a) through the first filter, so that the medicine in the medicine-containing hole is discharged to the exterior through a medicine passage (18) of the inner cylinder and the medicine discharge passage (20a) of the nozzle; and wherein a second hole (10b) and a second filter-fitting portion (11b) are provided in the bottom portion of the container, a second filter (13) coarser than the first filter (12) is fitted to the second filter-fitting portion, and the second filter and the second hole are communicated with the medicine passage (18) in the inner cylinder at the filling position.