# US 7,610,076 B2 · Method for acquiring time-resolved MR images using continuous table motion

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- Number: US 7,610,076 B2
- Document ID: US7610076B2
- Status: Granted
- Kind: B2
- Application number: 10/795,044
- Filed: 2004-03-05
- Published: 2004-10-21
- Granted: 2009-10-27
- Earliest claimed: 2003-03-07
- Assignees: Mayo Foundation for Medical Education and Research
- Inventors: Stephen J. Riederer; David G. Kruger; Ananth J. Madhuranthakam
- Web page: https://patentgrep.com/patent/US7610076B2

## CPC

- G01R 33/4824: {using a non-Cartesian trajectory}
- G01R 33/561: by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
- G01R 33/56375: {Intentional motion of the sample during MR, e.g. moving table imaging}
- G01R 33/281: {Means for the use of in vitro contrast agents (G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002)}
- G01R 33/5619: {by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]}
- G01R 33/56308: {Characterization of motion or flow; Dynamic imaging}
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)

## Abstract

MRA data is acquired from an extended field of view by translating the patient through the bore of the MRI system as three-dimensional MRA data sets are acquired and time-resolved images reconstructed. The leading edge of a contrast bolus can be tracked in these images and parameters such as bolus velocity and bolus arrival time can be calculated to provide functional information in addition to anatomical information. Temporal resolution is improved by undersampling peripheral k-space and sampling the center of k-space at a higher temporal rate.

## Claims

### Claim 1

In a magnetic resonance imaging (MRI) system having a defined field of view (FOV), a method for producing a series of time-resolved images of a subject over an extended field of view (FOVtot) which is larger than the FOV, the steps comprising:
a) moving the subject through the MRI system such that the extended field of view (FOVtot) passes through the defined field of view (FOV);
b) acquiring three-dimensional image data while step a) is performed by repeatedly performing a three-dimensional pulse sequence with the MRI system to repeatedly sample three-dimensional k-space in accordance with a prescribed sampling pattern by stepping a phase encoding gradient through a prescribed series of values in a succession of phase encoding cycles, and in which the prescribed sampling pattern fully samples a central region of k-space and undersamples a peripheral region of k-space for each phase encoding cycle;
c) adjusting the three-dimensional image data acquired in step b) to offset table motion during its acquisition; and
d) reconstructing a series of time resolved, three-dimensional images from the adjusted three-dimensional image data acquired at successive times.

### Claim 2 (depends on 1)

The method as recited in claim 1 in which the MRI system has a table, and step a) is performed by:
i) placing the subject on the table; and
ii) moving the table.

### Claim 3 (depends on 2)

The method as recited in claim 2 in which the table is moved continuously while performing step a).

### Claim 4 (depends on 2)

The method as recited in claim 2 in which the table is moved at different velocities while performing step a).

### Claim 5 (depends on 2)

The method as recited in claim 2 which includes: injecting the subject with a contrast agent; and
in which the table is moved at a velocity which tracks the contrast agent as it moves through the extended field of view (FOVtot).

### Claim 6 (depends on 1)

The method as recited in claim 1 in which said peripheral region of k-space includes a radial sector of k-space that extends outward from the central region.

### Claim 7 (depends on 1)

The method as recited in claim 1 in which said peripheral region of k-space includes a plurality of radial sectors of k-space that extend outward from the central region.

### Claim 8 (depends on 7)

The method as recited in claim 7 in which different radial sectors are sampled during successive phase encoding cycles.

### Claim 9 (depends on 7)

The method as recited in claim 7 in which said radial sectors are distributed around the central region of k-space.

### Claim 10 (depends on 1)

The method as recited in claim 1 in which the peripheral region of k-space sampled by the prescribed sampling pattern includes a first annular region that encircles the central region of k-space, and a second annular region that encircles the first annular region.

### Claim 11 (depends on 10)

The method as recited in claim 10 in which during each phase encoding cycle the central region of k-space is fully sampled and a portion of said first and second annular regions are sampled.

### Claim 12 (depends on 11)

The method as recited in claim 11 in which all of the prescribed samples in the first annular region are acquired in two successive phase encoding cycles.

### Claim 13 (depends on 12)

The method as recited in claim 12 in which all the prescribed samples in the second annular region are acquired in four successive phase encoding cycles.

### Claim 14 (depends on 10)

The method as recited in claim 10 in which the prescribed sampling pattern samples radial sectors of said first and second annular regions.

### Claim 15

In a magnetic resonance imaging (MRI) system having a defined field of view (FOV), a method for producing an image of a subject over an extended field of view (FOVtot) which is larger than the FOV, the steps comprising:
a) injecting a contrast agent into the subject;
b) moving the subject through the MRI system such that the extended field of view (FOVtot) passes through the defined field of view (FOV);
c) acquiring three-dimensional image data while step b) is performed by repeatedly performing a three-dimensional pulse sequence with the MRI system to repeatedly sample three-dimensional k-space in accordance with a prescribed sampling pattern, in which the prescribed sampling pattern fully samples a central region of k-space and undersamples a peripheral region of k-space;
d) adjusting the three-dimensional image data acquired in step c) to offset table motion during its acquisition;
e) reconstructing a series of time resolved, three-dimensional images from the adjusted three-dimensional image data acquired at successive times;
f) examining the magnitude of pixels in the reconstructed series of time resolved, three-dimensional images to determine when contrast agent arrived therein; and
g) reconstructing an image from adjusted three-dimensional image data that depicts the contrast enhanced vasculature of the subject throughout the extended field of view (FOVtot).

### Claim 16 (depends on 15)

The method as recited in claim 15 in which the image of the subject's vasculature is color modulated using the arrival times determined in step f) to indicate when contrast agent arrived at each location therein.

### Claim 17 (depends on 15)

The method as recited in claim 15 which includes calculating the contrast agent arrival time as a function of location along the axis of motion from the arrival times determined in step f).

### Claim 18 (depends on 17)

The method as recited in claim 17 which includes calculating the contrast agent velocity as a function of location along the axis of motion from the calculated function of contrast agent arrival times.

### Claim 19 (depends on 15)

The method as recited in claim 15 in which repeatedly performing the three-dimensional pulse sequence includes stepping a phase encoding gradient through a prescribed series of values.

### Claim 20 (depends on 19)

The method as recited in claim 19 in which the prescribed sampling pattern samples radial sectors of said peripheral region of k-space.

### Claim 21 (depends on 19)

The method as recited in claim 19 in which the prescribed sampling pattern samples radial sectors of annular regions of peripheral k-space.