# US 7,610,074 B2 · Multi-functional plasmon-resonant contrast agents for optical coherence tomography

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- Number: US 7,610,074 B2
- Document ID: US7610074B2
- Status: Granted
- Kind: B2
- Application number: 10/753,972
- Filed: 2004-01-08
- Published: 2005-08-04
- Granted: 2009-10-27
- Earliest claimed: 2004-01-08
- Assignees: The Board of Trustees of the University of Illinois; Purdue Research Foundation
- Inventors: Stephen A. Boppart; Alexander Wei
- Web page: https://patentgrep.com/patent/US7610074B2

## CPC

- A61B 5/416: {the spleen}
- A61K 41/0052: {Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy}
- A61K 49/0065: {the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle}
- A61K 49/0093: {Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle}
- B82Y 5/00: Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- G01N 21/4795: {spatially resolved investigating of object in scattering medium (in vivo A61B)}
- A61B 5/0059: {using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455)}
- A61B 5/0066: {Optical coherence imaging}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A method of forming an image of a sample, comprising: forming an image of a mixture, by exposing the mixture to electromagnetic radiation; wherein the mixture comprises the sample and plasmon-resonant nanoparticles, and wherein the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.

## Claims

### Claim 1

A method of forming an image by optical coherence tomography, comprising:
forming an image of a mixture by exposing the mixture to electromagnetic radiation; wherein the mixture comprises a patient and plasmon-resonant nanoparticles, wherein the electromagnetic radiation is provided to the mixture using optical coherence tomography in the frequency range of infra-red to ultraviolet light, and wherein the plasmon-resonant nanoparticles are anisotropic metallic nanoparticles having an extinction coefficient of at least 106M−1cm−1 at a frequency in the range of 1012 to 1017 Hz, wherein the anisotropic metallic nanoparticles comprise a magnetic metal, and wherein the magnetic metal is selected from nickel, cobalt, iron, and combinations thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein the anisotropic metallic nanoparticles comprise nanorods or nanotriangles.

### Claim 3 (depends on 1)

The method of claim 1, wherein the an isotropic metallic nanoparticles comprise gold.

### Claim 4 (depends on 1)

The method of claim 1, wherein the anisotropic metallic nanoparticles further comprise a surface modification.

### Claim 5 (depends on 4)

The method of claim 4, wherein the surface modification comprises a cross-linked surfactant shell.

### Claim 6 (depends on 5)

The method of claim 5, wherein the cross-linked surfactant shell comprises at least one member selected from the group consisting of cross-linked resorcinarenes and cross-linked olefin.

### Claim 7 (depends on 6)

The method of claim 6, further comprising, attached to the cross-linked surfactant shell, at least one member selected from the group consisting of folate, a monoclonal antibody, and a membrane receptor ligand.

### Claim 8 (depends on 1)

The method of claim 1, further comprising exposing the mixture to magnetic field.

### Claim 9 (depends on 1)

The method of claim 1, further comprising exposing the mixture to an electric field.

### Claim 10 (depends on 1)

The method of claim 1, wherein the patient is a human patient.

### Claim 11

A method of forming an image by optical coherence tomography, comprising:
administering to a patient, anisotropic metallic nanoparticles having an extinction coefficient of at least 106M−1cm−1 at a frequency in the range of 1012 to 1017 Hz;
wherein the anisotropic metallic nanoparticles are gold nanorods with a magnetic tip, and wherein the magnetic tip is one metal selected from the group consisting of cobalt, nickel, and iron;
exposing the patient to electromagnetic radiation;
collecting reflected electromagnetic radiation; and
forming an enhanced contrast image from the collected electromagnetic radiation.

### Claim 12 (depends on 11)

The method of claim 11, wherein the gold nanorods have an aspect ratio of 4:1 to 10:1 and a diameter of 10 nm to 100 nm.

### Claim 13 (depends on 11)

The method of claim 11, wherein the patient is a human.