Methods of detection of iron deficiency and hemochromatosis
AssigneeBeckman Coulter, Inc.
InventorRamon Simon-Lopez
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Abstract
New diagnostic parameters or indexes for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency have been disclosed. The parameters include a RBC size factor, RSf1 defined by the formula of (MCV×MRV)1/2, or RSf2 defined by the formula of (MCV×MRV)/100, a volume-hemoglobin factor (VHf) defined by the formula of (MCV×Hgb)/100, and a volume-hemoglobin/distribution factor (VHDWf) defined by the formula of (MCV×Hgb)/(RDW×10). Further disclosed are the methods of using these parameters for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency. Also disclosed is a method of using RSf for detection of hemochromatosis.
Claims6
A method of detection of iron deficiency comprising the steps of:
- (a) analyzing a blood sample of said patient on a hematology analyzer and obtaining a mean cell volume of red blood cells (MCV) and a total hemoglobin concentration (Hgb) of said blood sample;
- (b) obtaining a volume-hemoglobin factor (VHf) of said blood sample, defined as a product function of said MCV and said Hgb;
- (c) comparing said VHf obtained in step (b) to a predetermined criterion of VHf defining iron deficiency;
- and
- (d) reporting an indication of iron deficiency if obtained VHf meets said predetermined criterion.
Dependencies are inferred from the claim text.