# US 7,608,705 B2 · Oligonucleotides, agents containing these oligonucleotides, and the use thereof

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- Number: US 7,608,705 B2
- Document ID: US7608705B2
- Status: Granted
- Kind: B2
- Application number: 10/381,869
- Filed: 2001-09-28
- Published: 2005-01-27
- Granted: 2009-10-27
- Earliest claimed: 2000-09-28
- Assignees: Universitatsklinikum Schleswig-Holstein
- Applicants: Inge Bayer, legal representative
- Inventors: Ernst Bayer; Thomas Ketterer; Holger Kalthoff; Hendrik Ungefroren; Michael Gerster; Alexander Fiedler
- Web page: https://patentgrep.com/patent/US7608705B2

## CPC

- C12N 15/117: Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
- A61K 2039/55561: {CpG containing adjuvants; Oligonucleotide containing adjuvants}
- C12N 2310/18: acting by a non-sequence specific mechanism
- C12N 2310/315: Phosphorothioates
- C12N 2310/351: Conjugate
- C12N 2310/3515: Lipophilic moiety, e.g. cholesterol
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The invention relates to particular oligonucleotides, pharmaceutical agents that contain these oligonucleotides, and to the therapeutic use thereof. The oligonucleotides are, in particular, capable of inhibiting the proliferation of pancreatic tumors. These oligonucleotides thus have a therapeutic potential for the treatment of pancreatic tumors. This can involve, in the broadest sense, an antisense therapy.

## Claims

### Claim 1

An oligonucleotide consisting of:
5′-tocopheryl-TGC TCC CCC CTG GCT-3′-PEG1500 (SEQ ID NO:1); or
5′-tocopheryl-TGC TCC CCC CTG GCT-3′-tocopheryl (SEQ ID NO:1).

### Claim 2 (depends on 1)

Pharmaceutical agent containing at least one oligonucleotide according to claim 1, and optionally pharmaceutically acceptable auxiliary agents.