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US 7,608,685 B1Granted
Tumor antigen based on products of the tumor suppressor gene WT1
AssigneeInternational Institute of Cancer Immunology, Inc.
InventorsHaruo Sugiyama, Yoshihiro Oka
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Abstract
A tumor antigen that comprises, as an active ingredient, a product of the Wilms' tumor suppressor gene WT1 or a peptide composed of 7-30 contiguous amino acids containing an anchor amino acid for binding to major histocompatibility complex (MHC) class I in said amino acid sequence, and a vaccine comprising said antigen.
Claims9
An isolated polypeptide which consists of 7 to 30 contiguous amino acid residues of WT1 protein, wherein
- the polypeptide binds to MHC proteins, and
- the polypeptide induces killer T cells when bound to MHC class I antigen.
Dependencies are inferred from the claim text.