# US 7,608,678 B2 · Hydrolytically degradable polymers and hydrogels made therefrom

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- Number: US 7,608,678 B2
- Document ID: US7608678B2
- Status: Granted
- Kind: B2
- Application number: 11/890,162
- Filed: 2007-08-03
- Published: 2007-11-29
- Granted: 2009-10-27
- Earliest claimed: 1999-12-10
- Assignees: Nektar Therapeutics
- Inventors: J. Milton Harris; Michael D. Bentley; Xuan Zhao; Xiaoming Shen
- Web page: https://patentgrep.com/patent/US7608678B2

## CPC

- C08G 64/0208: {saturated}
- C08G 64/0216: {containing a chain-terminating or -crosslinking agent}
- C08G 64/183: {containing polyether sequences}
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS

## Abstract

A water soluble polymer is described, the water soluble polymer comprising multiple hydrolytically degradable carbonate linkages in a backbone and, for each carbonate linkage in the backbone, an oligomer linked thereto by the carbonate linkage, wherein the oligomer is branched and, prior to being linked by the carbonate linkage, has the formula: R3[O—(—CHR1CH2—O—)n—]mH where R3 is a core branching moiety, R1 is H, (n) can range from 2 to 2000, and m is at least 3.

## Claims

### Claim 1

A water soluble polymer comprising multiple hydrolytically degradable carbonate linkages in a backbone and, for each carbonate linkage in the backbone, an oligomer linked thereto by the carbonate linkage, wherein the oligomer is branched and, prior to being linked by the carbonate linkage, has the formula:
R3[O—(—CHR1CH2—O—)n—]mH
where R3 is a core branching moiety, R1 is H, (n) can range from 2 to 2000, and m is at least 3.

### Claim 2 (depends on 1)

The polymer of claim 1, wherein (n) is 5 to 500.

### Claim 3 (depends on 1)

The polymer of claim 1, wherein (n) is 10 to 50.