# US 7,608,642 B2 · Wound and skin care compositions

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- Number: US 7,608,642 B2
- Document ID: US7608642B2
- Status: Granted
- Kind: B2
- Application number: 10/463,207
- Filed: 2003-06-17
- Published: 2004-06-17
- Granted: 2009-10-27
- Earliest claimed: 2002-12-16
- Assignees: Kimberly-Clark Worldwide, Inc.
- Inventors: Sohail Malik
- Web page: https://patentgrep.com/patent/US7608642B2

## CPC

- A61K 31/52: Purines, e.g. adenine
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A61K 31/365: Lactones
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 31/60: Salicylic acid; Derivatives thereof
- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention provides compositions and methods that employ compounds that can promote skin cell renewal, wound healing, proliferation of fibroblasts and/or keratinocytes, and production of collagen or fibronectin by fibroblasts. These compositions and methods are useful for rejuvenating the skin and for treating wounds as well as gum-related and skin-related conditions.

## Claims

### Claim 1

A method of promoting healthy skin development in a mammal comprising topically administering to the mammal a safe and effective amount of a composition comprising a dermatologically acceptable carrier, an amount of a jasmonic acid compound effective for stimulating fibronectin production in mammalian fibroblasts and keratinocyte cell growth, and an amount of a compound selected from the group consisting of a gibberellic acid compound, a zeatin compound, and combinations thereof, to thereby promote healthy skin development in the mammal, wherein the concentration of the jasmonic acid compound is about 10−4 M to about 10−6 M.

### Claim 2

A method of promoting healthy skin development in a mammal comprising topically administering to the mammal a safe and effective amount of a composition comprising a dermatologically acceptable carrier and an amount of a jasmonic acid compound effective for stimulating fibronectin production in mammalian fibroblasts and keratinocyte cell growth to thereby promote healthy skin development in the mammal, wherein the concentration of the jasmonic acid compound is about 10−4 M to about 10−6 M.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition comprises an effective amount of a gibberellic acid compound.

### Claim 4 (depends on 1)

The method of claim 1, wherein the effective amount of the jasmonic acid compound, the gibberellic acid compound, or the zeatin compound is a concentration of about 0.01% to about 50% of the composition.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition comprises an effective amount of a zeatin compound.

### Claim 6 (depends on 1)

The method of claim 1, wherein the gibberellic acid compound is a compound of any one of formulae III, IV, V, Va, or Vb:

### Claim 7 (depends on 1)

The method of claim 1, wherein the jasmonic acid compound is a compound of any one of formulae VI-IX:
wherein:
R3 is alkyl;
R4 is COOR or —(CH2)n—OX, where n is an integer of from 1 to 20;
R is H or alkyl;
X is H, or 1 to 6 sugar residues; and
Y is H, alkyl, or 1 to 6 sugar residues.

### Claim 8 (depends on 1)

The method of claim 1, wherein the jasmonic acid compound is jasmonic acid, hydroxyjasmonic acid, dihydrojasmonic acid, or dihydro-hydroxyjasmonic acid.

### Claim 9 (depends on 1)

The method of claim 1, wherein the zeatin compound is a compound of formula X:
wherein:
R5 is H, 3-hydroxymethyl-3-methylallyl, alkyl, —(CH2)n—CH3, or OZ;
Z is H, 1 to 6 sugar residues, or —(CH2)n-furan;
R6 is H, 3-hydroxymethyl-3-methylallyl, alkyl, —(CH2)n—CH3, or OZ; and
n is an integer of 1 to 20.

### Claim 10 (depends on 1)

The method of claim 1, wherein the zeatin compound is zeatin.

### Claim 11 (depends on 1)

The method of claim 1, wherein the composition further comprises a salicylate compound.

### Claim 12 (depends on 11)

The method of claim 11, wherein the salicylate compound is a compound of formula I:
wherein:
R1 is COOR or —(CH2)n—OX;
R is H or C1-C20 alkyl;
n is an integer of about 1 to about 20;
X is H or 1 to 6 sugar residues;
R2 is COOR, —(CH2)n—OX, OCO—(C1-C20)alkyl, OY; and
Y is H, C1-C20 alkyl, or 1 to 6 sugar residues.

### Claim 13 (depends on 11)

The method of claim 11, wherein the salicylate compound is salicylic acid or acetylsalicylic acid.

### Claim 14 (depends on 1)

The method of claim 1, wherein the composition further comprises one or more additional ingredients wherein the additional ingredient is a desquamation compound, an anti-acne compound, an anti-wrinkle compound, a vitamin B3 compound a vitamin E compound, a retinoid compound, a hydroxy acid compound, an anti-oxidant compound, a chelating agent, a flavonoid compound, an anti-inflammatory agent, an anti-cellulite agent, a topical anesthetic, a tanning compound, a skin lightening agent, a skin healing compound, an antimicrobial compound, an antifungal compound, a sunscreen compound, a particulate material, a moisturizer, or a thickening agent.

### Claim 15 (depends on 14)

The method of claim 14, wherein the vitamin E compound is tocopherol, tocopherol acetate, a tocopherol ester or a mixture thereof.

### Claim 16 (depends on 14)

The method of claim 14, wherein the retinoid compound is a retinol, retinal, retinol ester, retinyl propionate, retinoic acid, retinyl palmitate, or a mixture thereof.

### Claim 17 (depends on 14)

The method of claim 14, wherein the particulate material is mica, mica treated with barium sulfate and TiO2, silica, nylon, polyethylene, talc, styrene, polypropylene, ethylene/acrylic acid copolymer, sericite, aluminum oxide, silicone resin, barium sulfate, titanium dioxide, iron oxide, bismuth oxychloride, calcium carbonate, cellulose acetate, polymethyl methacrylate, or a mixture thereof.

### Claim 18 (depends on 14)

The method of claim 14, wherein the sunscreen compound is a metallic oxide selected from the group consisting of titanium dioxide having an average primary particle size of from about 15 nm to about 100 nm, zinc oxide having an average primary particle size of from about 15 nm to about 150 nm, zirconium oxide having an average primary particle size of from about 15 nm to about 150 nm, iron oxide having an average primary particle size of from about 15 nm to about 500 nm, or a mixture thereof.

### Claim 19 (depends on 14)

The method of claim 14, wherein the sunscreen compound is octylmethoxycinnamate, octyl salicylate, terephthalyidene dicamphor sulfonic acid, avobenzone, octocrylene, or a mixture thereof.