# US 7,608,641 B2 · Creatine oral supplementation using creatine hydrochloride salt

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 7,608,641 B2
- Document ID: US7608641B2
- Status: Granted
- Kind: B2
- Application number: 10/846,782
- Filed: 2004-05-14
- Published: 2004-12-02
- Granted: 2009-10-27
- Earliest claimed: 2003-05-15
- Assignees: Board of Regents of the University of Nebraska
- Inventors: Donald W. Miller; Jonathan L. Vennerstrom; Mark C. Faulkner
- Web page: https://patentgrep.com/patent/US7608641B2

## CPC

- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A23K 20/105: Aliphatic or alicyclic compounds
- A23K 20/142: Amino acids; Derivatives thereof
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A61P 21/06: Anabolic agents (androgens A61P5/26)
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Creatine oral supplementation using creatine hydrochloride salt, that may be added to a liquid or other beverage, or may be also used as an additive to solid oral dosages, or as a supplement, and which may be consumed by the athlete, or other party looking for immediate supplementation of strength, and may be added as a supplement within feed to livestock, in the veterinary area.

## Claims

### Claim 1

A supplement to increase muscle mass and muscle performance consisting of creatine hydrochloride salt formed from the reaction product of:
about 0.8 to about 1.2 mole equivalent creatine monohydrate; and
about 1.1 to about 1.4 mole equivalents acetyl chloride,
dissolved in about 6 to about 10 milliliters alcohol solution per gram of creatine hydrochloride salt at a temperature of about 25° C. to about 35° C.,
wherein the supplement has an aqueous solubility of at least 150 mg/ml.

### Claim 2 (depends on 1)

The supplement of claim 1, wherein the reaction product is formed from:
about 1 mole equivalent creatine monohydrate; and
about 1.4 mole equivalents acetyl chloride dissolved in about 10 milliliters ethanol solution.

### Claim 3 (depends on 2)

The supplement of claim 2, wherein the supplement is precipitated as granules and then packaged into an oral dosage form.

### Claim 4 (depends on 1)

The supplement of claim 1, wherein the supplement has an aqueous solubility of at least an order of magnitude higher than the aqueous solubility of creatine monohydrate.

### Claim 5 (depends on 1)

The supplement of claim 1, wherein the yield of creatine hydrochloride salt is approximately 94 percent.

### Claim 6

A supplement for to increase muscle mass and muscle performance consisting of creatine hydrochloride salt formed from the reaction product of:
about 1 mole equivalent creatine monohydrate:
about 1.4 mole equivalents acetyl chloride;
said creatine monohydrate and said acetyl chloride dissolving in about 10 milliliters ethanol solution at a temperature of about 25° C. forming a solution of creatine hydrochloride having an aqueous solubility of at least 150 mg/ml; and
thus precipitating granules of creatine hydrochloride salt from the solution for oral dosage as one pill, capsule, tablet, or liquid.

### Claim 7 (depends on 6)

The supplement of claim 6, wherein the yield of creatine hydrochloride salt is approximately 94 percent.