# US 7,608,638 B2 · Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof

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- Number: US 7,608,638 B2
- Document ID: US7608638B2
- Status: Granted
- Kind: B2
- Application number: 11/876,612
- Filed: 2007-10-22
- Published: 2008-05-22
- Granted: 2009-10-27
- Earliest claimed: 1998-09-23
- Assignees: Research Development Foundation
- Inventors: Bob G. Sanders; Kimberly Kline; Daurence Hurley; Robb Gardner; Marla Menchaca; Weiping Yu; Puthucode N. Ramanan; Shenquan Liu; Karen Israel
- Web page: https://patentgrep.com/patent/US7608638B2

## CPC

- C07D 215/46: with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
- A61P 5/14: of the thyroid hormones, e.g. T3, T4
- A61P 17/00: Drugs for dermatological disorders
- A61P 19/00: Drugs for skeletal disorders
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 21/04: for myasthenia gravis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/12: Antivirals
- A61P 31/18: for HIV
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 35/04: specific for metastasis
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- C07D 215/38: Nitrogen atoms (nitro radicals C07D215/18)
- C07D 311/58: other than with oxygen or sulphur atoms in position 2 or 4
- C07D 311/66: with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D 311/72: 3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
- C07D 311/76: Benzo[c]pyrans
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.

## Claims

### Claim 1

A compound of the formula:
wherein:
R1 is hydroxy or methoxy;
R2 and R3 are independently hydrogen or methyl.

### Claim 2 (depends on 1)

The compound of claim 1, wherein R1 is hydroxy.

### Claim 3 (depends on 1)

The compound of claim 1, wherein R1 is methoxy.

### Claim 4 (depends on 1)

The compound of claim 1, wherein R2 is hydrogen.

### Claim 5 (depends on 1)

The compound of claim 1, wherein R2 is methyl.

### Claim 6 (depends on 1)

The compound of claim 1, wherein R3 is hydrogen.

### Claim 7 (depends on 1)

The compound of claim 1, wherein R3 is methyl.

### Claim 8 (depends on 1)

The compound of claim 1, further defined as:
wherein:
R1 is hydroxy or methoxy; and
R2 and R3 are independently hydrogen or methyl.

### Claim 9

A compound of the formula:

### Claim 10

A compound of the formula: