# US 7,608,628 B2 · Alkylsulphonamide quinolines

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- Number: US 7,608,628 B2
- Document ID: US7608628B2
- Status: Granted
- Kind: B2
- Application number: 11/609,166
- Filed: 2006-12-11
- Published: 2008-01-24
- Granted: 2009-10-27
- Earliest claimed: 2005-12-12
- Assignees: AstraZeneca AB
- Inventors: Thomas R. Simpson; James Kang; Jeffrey S. Albert; Cristobal Alhambra; Gerald M. Koether; James Woods; Yan Li
- Web page: https://patentgrep.com/patent/US7608628B2

## CPC

- C07D 215/38: Nitrogen atoms (nitro radicals C07D215/18)
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 1/08: for nausea, cinetosis or vertigo; Antiemetics
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 5/00: Drugs for disorders of the endocrine system
- A61P 5/06: of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P 5/28: Antiandrogens
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 13/08: of the prostate
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 25/22: Anxiolytics
- A61P 25/24: Antidepressants
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 215/14: Radicals substituted by oxygen atoms
- C07D 215/52: with aryl radicals attached in position 2
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds of Formula II wherein R1, A, R2, R3, R4, R5, R8, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

## Claims

### Claim 1

A compound that is 3-methanesulfonylamino-2-phenyl-quinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide, or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A pharmaceutical composition comprising the compound according to claim 1 together with at least one pharmaceutically acceptable diluent, lubricant or carrier.