# US 7,608,616 B1 · Methods for reducing the risk of an adverse drug interaction in a patient suffering from insomnia

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 7,608,616 B1
- Document ID: US7608616B1
- Status: Granted
- Kind: B1
- Application number: 12/132,575
- Filed: 2008-06-03
- Granted: 2009-10-27
- Earliest claimed: 2008-06-03
- Assignees: Questcor Pharmaceuticals, Inc.
- Inventors: Steve Cartt
- Web page: https://patentgrep.com/patent/US7608616B1

## CPC

- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 31/12: Ketones
- A61K 31/135: having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)}
- A61K 31/55: having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Disclosed herein is a method for treating a patient with Quazepam that reduces the risk of an adverse interaction between the Quazepam and drug that is a substrate of the cytochrome P450 enzyme isoform 2B6 (CYP2B6 substrate drug), e.g., Bupropion. The method includes determining if the patient to be treated with Quazepam is being treated with a CYP2B6 substrate drug, and prescribing or treating the patient with Quazepam based on the determination.

## Claims

### Claim 1

A method for reducing the risk of an adverse drug interaction in a patient suffering from depression, comprising
(i) determining if the patient is also suffering from insomnia and is being treated with bupropion, and
(ii) prescribing or administering to the patient a therapeutically effective amount of quazepam to treat the insomnia if and only if the patient is not being treated with bupropion.

### Claim 2 (depends on 1)

The method of claim 1, wherein the patient is not being treated with bupropion, further comprising prescribing or administering to the patient an antidepressant drug other than bupropion.