# US 7,608,588 B2 · Mineral collagen chelates and methods of making and using same

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- Number: US 7,608,588 B2
- Document ID: US7608588B2
- Status: Granted
- Kind: B2
- Application number: 12/271,293
- Filed: 2008-11-14
- Published: 2009-03-05
- Granted: 2009-10-27
- Earliest claimed: 2005-10-13
- Inventors: Jennifer L. Gu; Edward Lee
- Web page: https://patentgrep.com/patent/US7608588B2

## CPC

- C12P 21/06: produced by the hydrolysis of a peptide bond, e.g. hydrolysate products (preparing foodstuffs by protein hydrolysis A23J3/00)
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- C07K 14/78: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Collagen peptide chelated mineral products, pharmaceutical formulations thereof and methods for preparing same are provided. Also provided is a method for generating the optimal size of collagen peptide for optimum mineral chelation as well as optimum biological function for supporting bone health and joint health. Also disclosed are methods of increasing bone density/preventing osteoporosis, of reducing joint pain and/or joint deterioration from osteoarthritis, degenerative joint disease, joint defect, and rheumatoid arthritis.

## Claims

### Claim 1

A method of supporting mineral homeostasis, promoting bone strength or treatment of diseases associated with a loss of minerals comprising administering to a mammal a composition for oral administration comprising a mineral collagen chelate compound comprising collagen peptides having an average molecular weight of 0.2 KD to 50 KD, at least one mineral and a pharmaceutically acceptable excipient.

### Claim 2

A method of supporting bone health, increasing bone mineral density and/or increasing bone strength comprising administering to a mammal in need thereof a composition for oral administration comprising a mineral collagen chelate compound comprising collagen peptides having an average molecular weight of 0.2 KD to 50 KD, at least one mineral and a pharmaceutically acceptable excipient.