# US 7,608,581 B2 · Biofunctional, antimicrobial coatings for medical devices > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,608,581 B2 - Document ID: US7608581B2 - Status: Granted - Kind: B2 - Application number: 11/638,973 - Filed: 2006-12-14 - Published: 2007-05-10 - Granted: 2009-10-27 - Earliest claimed: 2004-06-16 - Assignees: Affinergy, Inc. - Inventors: Paul Hamilton; Daniel Kenan; Mark Grinstaff - Web page: https://patentgrep.com/patent/US7608581B2 ## CPC - A61L 27/227: {Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24} - A61L 27/34: Macromolecular materials - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61P 19/00: Drugs for skeletal disorders - C07K 7/08: having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) - C07K 14/001: {by chemical synthesis} - A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2300/606: Coatings - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating. ## Claims ### Claim 1 A medical device comprising at least one surface coated with a coating for imparting antimicrobial activity to the medical device, wherein the coating comprises a surface-binding domain coupled to an antimicrobial-binding domain, wherein the surface-binding domain comprises a peptide that binds non-covalently to a material of which the medical device is comprised, and wherein the antimicrobial-binding domain comprises a peptide that binds non-covalently to an antibiotic composition. ### Claim 2 (depends on 1) The medical device according to claim 1, wherein the material to which the surface-binding domain binds comprises a material selected from the group consisting of metal, metal oxide, non-metal oxide, ceramic, polymer, and a combination thereof. ### Claim 3 (depends on 1) The medical device according to claim 1, wherein the coating comprises more than one type of surface-binding domain for binding to more than one type of surface material of the medical device. ### Claim 4 (depends on 1) The medical device according to claim 1, wherein the antimicrobial-binding domain is bound to the antibiotic composition. ### Claim 5 (depends on 1) The medical device according to claim 1, wherein the coating comprises more than one type of antimicrobial-binding domain for binding to more than one type of antibiotic composition. ### Claim 6 (depends on 1) The medical device according to claim 1, wherein the surface-binding domain is coupled to the antimicrobial-binding domain via a linker. ### Claim 7 (depends on 1) The medical device according to claim 1, wherein the surface-binding domain comprises a peptide consisting of 12 to 20 amino acids in length and, optionally, is modified at one or more amino acids with a chemical group, and wherein the antimicrobial-binding domain comprises a peptide consisting of 13 to 20 amino acids in length and, optionally, is modified at one or more amino acids with a chemical group. ### Claim 8 (depends on 1) The medical device of claim 1, wherein the antibiotic composition comprises vancomycin. ### Claim 9 (depends on 1) A method for manufacturing a medical device according to claim 1, the method comprising contacting a medical device with an effective amount of a coating to produce a medical device having at least one surface coated by the coating; wherein the coating comprises a surface-binding domain coupled to an antimicrobial-binding domain; wherein the surface-binding domain comprises a peptide that binds non-covalently to a material of which the medical device is comprised, and the antimicrobial-binding domain comprises a peptide that binds non-covalently to an antibiotic composition. ### Claim 10 (depends on 9) The method according to claim 9, wherein the antimicrobial-binding domain is bound to the antibiotic composition. ### Claim 11 (depends on 9) The method according to claim 9, wherein the coating comprises more than one type of antimicrobial-binding domain for binding to more than one type of antibiotic composition. ### Claim 12 (depends on 9) The method according to claim 9, wherein the coating comprises more than one type of surface-binding domain for binding to more than one type of surface material of the medical device. ### Claim 13 (depends on 9) The method according to claim 9, wherein the material to which the surface-binding domain binds comprises a material selected from the group consisting of a metal, a metal oxide, a non-metal oxide, a ceramic, a polymer, and a combination thereof. ### Claim 14 (depends on 9) The method according to claim 9, wherein the surface-binding domain is coupled to the antimicrobial-binding domain via a linker. ### Claim 15 (depends on 9) The method of claim 9, wherein the antibiotic composition comprises vancomycin.