# US 7,608,578 B2 · Obesity controlling method

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- Number: US 7,608,578 B2
- Document ID: US7608578B2
- Status: Granted
- Kind: B2
- Application number: 10/343,668
- Filed: 2001-08-09
- Published: 2004-01-15
- Granted: 2009-10-27
- Earliest claimed: 2000-08-11
- Assignees: Temple University of the Commonwealth System of Higher Education
- Inventors: Larry S. Miller
- Web page: https://patentgrep.com/patent/US7608578B2

## CPC

- A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61F 5/0079: {Pyloric or esophageal obstructions}
- A61K 38/39: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A61P 3/04: Anorexiants; Antiobesity agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding stomach emptying and producing a feeling of satiation in the patient. The method may be supplemental and augmented by inducing flaccid paralysis of the stomach by injecting botulinum toxin into the muscle tissue of the antrum or fundus of the stomach.

## Claims

### Claim 1

A method of treating obesity comprising:
injecting a bio-compatible bulking material submucosally or intramuscularly into the pyloric area of the stomach in an amount sufficient to cause the lumen of pylorus to narrow and slow gastric emptying;
sewing the pylorus to narrow the lumen; and
treating the pylorus wherein a laser or thermal device is placed through the biopsy channel and the pylorus is scarred with said device to narrow the lumen.

### Claim 2 (depends on 1)

The method of claim 1, wherein said bio-compatible bulking material comprises collagen, fibrin, or elastin.

### Claim 3 (depends on 2)

The method of claim 2, wherein said bio-compatible bulking material comprises collagen in one of the following forms: fibrillar, non-fibrillar, crosslinked, non-crosslinked, aqueous, or denatured gelatin.

### Claim 4 (depends on 1)

The method of claim 1, wherein said bio-compatible bulking material comprises a fluoropolymer resin paste, a synthetic polymeric hydrogel, a glycoaminoglycan, a proteoglycan, or microbeads suspended in a biological fluid lubricant.

### Claim 5 (depends on 1)

The method of claim 1, wherein said bio-compatible bulking material is injected through a needle inserted through a biopsy channel of an endoscope inserted into the stomach.

### Claim 6 (depends on 1)

The method of claim 1, wherein a sewing device is placed through the biopsy channel and the pylorus is sewn with said device.

### Claim 7 (depends on 1)

The method of claim 1, further comprising inducing supplemental flaccid paralyses of the stomach wherein a needle is placed through the biopsy channel and botulinum toxin is injected into the muscles of the fundus.

### Claim 8 (depends on 1)

The method of claim 1, further comprising inducing supplemental flaccid paralyses of the stomach wherein a needle is placed through the biopsy channel and botulinum toxin is injected into the antrum of the stomach.