# US 7,608,466 B2 · Process and device for producing reagent carriers

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- Number: US 7,608,466 B2
- Document ID: US7608466B2
- Status: Granted
- Kind: B2
- Application number: 11/156,855
- Filed: 2005-06-20
- Published: 2005-12-22
- Granted: 2009-10-27
- Earliest claimed: 2004-06-21
- Assignees: Roche Diagnostics Operations, Inc.
- Inventors: Hans Hornauer
- Web page: https://patentgrep.com/patent/US7608466B2

## CPC

- G01N 33/531: Production of immunochemical test materials
- B01J 19/0046: {Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays (synthesis methods per se C40B50/00)}
- G01N 33/54313: {the carrier being characterised by its particulate form}
- B01J 2219/00328: Movement by linear translation
- B01J 2219/00369: in multiple or parallel arrangements
- B01J 2219/00387: Applications using probes
- B01J 2219/00518: in the shape of tapes
- B01J 2219/00533: essentially rectangular
- B01J 2219/00596: Solid-phase processes
- B01J 2219/00605: the compounds being directly bound or immobilised to solid supports
- B01J 2219/0061: The surface being organic
- B01J 2219/00626: Covalent
- B01J 2219/0063: Other, e.g. van der Waals forces, hydrogen bonding
- B01J 2219/00637: by coating it with another layer
- B01J 2219/00657: One-dimensional arrays
- B01J 2219/00659: Two-dimensional arrays
- B01J 2219/00693: Means for quality control
- B01J 2219/0072: Organic compounds
- B01L 3/0268: {using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries}
- G01N 2035/00158: {Elements containing microarrays, i.e. "biochip"}
- G01N 2035/00168: {Manufacturing or preparing test elements}
- G01N 2035/1034: {Transferring microquantities of liquid}
- Y10T 436/11: Automated chemical analysis
- Y10T 436/110833: Utilizing a moving indicator strip or tape
- Y10T 436/112499: with sample on test slide
- Y10T 436/25: including sample preparation
- Y10T 436/2575: Volumetric liquid transfer
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

The invention concerns a process for producing reagent carriers having a binding capability that are suitable for determining analytes in liquids, wherein the process comprises at least one step of treating a respective reagent carrier body in particular by transferring material between a treatment device and the reagent carrier body in a preparation device and wherein this treatment step takes place on the moving reagent carrier body during its transport in the preparation device or during a movement of the treatment device relative to the reagent carrier body in the preparation device.

## Claims

### Claim 1

A process for producing reagent carriers comprising a reagent for binding an analyte, the process comprising:
providing reagent carrier bodies on a continually moving transport device,
providing a treatment device for treating the reagent carrier bodies, wherein the treatment device comprises one or more of a drying device, an irradiating device, an optical monitoring device, a removal device, and a release device,
transporting the carrier bodies via the transport device through a treatment zone wherein the treatment device remains positioned over the transport device through the treatment zone and wherein the treatment device and reagent carrier bodies move at a constant speed relative to one another through the treatment zone, and
treating each carrier body via the treatment device as the reagent carrier body moves during its transport through the treatment zone.

### Claim 2 (depends on 1)

The process of claim 1 wherein the treatment step occurs as the treatment device moves relative to the treatment zone.

### Claim 3 (depends on 1)

The process of claim 1 wherein the treatment device comprises at least one droplet generator comprising droplet discharge jets comprising a liquid provided from a liquid reservoir.

### Claim 4 (depends on 3)

The process of claim 3 wherein the treatment step further comprises removing a liquid from the reagent carrier bodies.

### Claim 5 (depends on 1)

The process of claim 1 wherein the reagent is streptavidin or HBc antigen.

### Claim 6 (depends on 3)

The process of claim 3 wherein the at least one droplet generator operates at a constant time frequency.

### Claim 7 (depends on 3)

The process of claim 3 wherein the release device comprises more than one droplet generator and each droplet generator operates at a different constant time frequency.