Identifying patients at risk for life threatening arrhythmias
AssigneeMedtronic, Inc.
InventorsOrhan Soykan, Amy C. Dearking, Timothy H. Robinson, Walter H. Olson, Vinod Sharma
Life of this patent
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Abstract
The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.
Claims25
A method of assessing a patient for risk of sudden cardiac death (SCD), the method comprising:
- determining an amount of at least one SCD-associated protein in the patient;
- assessing the risk as a function of the determination;
- determining occurrence of at least one class identifier that assesses the patient as having increased risk of SCD;
- combining results of the occurrence of the class identifier and the amount of SCD-associated protein;
- wherein assessing the patient is based on the combined results;
- and
- wherein the SCD-associated protein is selected from a group of proteins having characteristics consisting of 10,146.5 Da and pI=9+;
- 15,006 Da and pI=9+;
- 166,582 Da and pI=5-7;
- 10,948 Da and pI=9+;
- 11,991 Da and pI=5-7;
- 10,552.4 Da and pI=9;
- 43,529.4 Da and pI=9;
- and 13,806.8 Da and pI=9.
A method of identifying patients that would benefit from an implanted medical device, the method comprising:
- identifying at least one SCD-associated protein;
- determining an amount of SCD-associated protein from a protein-containing sample from a patient;
- assessing whether the patient would benefit from an implanted medical device based on the amount of the SCD-associated protein
- wherein the implanted medical device is an electronic stimulation device;
- and
- wherein the SCD-associated protein is selected from a group of proteins having characteristics consisting of 10,146.5 Da and pI=9+;
- 15,006 Da and pI=9+;
- 166,582 Da and DI=5-7;
- 10,948 Da and pI=9+;
- 11,991 Da and pI=5-7;
- 10,552.4 Da and pI=9;
- 43,529.4 Da and pI=9;
- and 13,806.8 Da and pI=9.
A method of identifying a SCD-associated protein comprising:
- collecting first protein-containing samples from patients having increased risk of SCD;
- collecting second protein-containing samples from patients having no increased risk of SCD;
- determining amounts of proteins in the first and second protein-containing samples;
- and
- identifying a protein having an amount that differs between the first and second protein-containing samples;
- wherein the SCD-associated protein is selected from a group of proteins having characteristics consisting of 10,146.5 Da and pI=9+;
- 15,006 Da and pI=9+;
- 166,582 Da and pI=5-7;
- 10,948 Da and pI=9+;
- 11,991 Da and pI=5-7;
- 10,552.4 Da and pI=9;
- 43,529.4 Da and pI=9;
- and 13,806.8 Da and pI=9.
A method of assessing a patient for risk of sudden cardiac death (SCD), the method comprising:
- determining an amount of at least one SCD-associated protein in the patient;
- and assessing the risk based on the determined amount of SCD-associated protein wherein the SCD-associated protein is selected from a group of proteins having characteristics consisting of 10,146.5 Da and pI=9+;
- 15,006 Da and pI=9+;
- 166,582 Da and pI=5-7;
- 10,948 Da and pI=9+;
- 11,991 Da and pI=5-7;
- 10,552.4 Da and pI=9;
- 43,529.4 Da and pI=9;
- and 13,806.8 Da and pI=9.
A method of identifying patients that would benefit from an implanted medical device, the method comprising:
- identifying at least one SCD-associated protein;
- determining an amount of SCD-associated protein from a protein-containing sample from a patient;
- assessing whether the patient would benefit from an implanted medical device based on the amount of the SCD-associated protein, wherein the SCD-associated protein is selected from a group of proteins having characteristics consisting of 10,146.5 Da and pI=9+;
- 15,006 Da and pI=9+;
- 166,582 Da and pI=5-7;
- 10,948 Da and pI=9+;
- 11,991 Da and pI=5-7;
- 10,552.4 Da and pI=9;
- 43,529.4 Da and pI=9;
- and 13,806.8 Da and pI=9.
A method of assessing a patient for risk of sudden cardiac death (SCD), the method comprising:
- determining the presence or absence of at least one SCD-associated protein in the patient;
- assessing the risk as a function of the determination;
- determining occurrence of at least one class identifier that assesses the patient as having increased risk of SCD;
- combining results of the occurrence of the class identifier;
- wherein assessing the patient is based on the combined results;
- and
- wherein the SCD-associated protein is selected from a group of proteins having characteristics consisting of 10,146.5 Da and pI=9+;
- 15,006 Da and pI=9+;
- 166,582 Da and pI=5-7;
- 10.948 Da and pI=9+;
- 11,991 Da and pI=5-7;
- 10,552.4 Da and pI=9;
- 43,529.4 Da and pI=9;
- and 13,806.8 Da and pI=9.
Dependencies are inferred from the claim text.