# US 7,608,452 B2 · Polynucleotides encoding cytokine receptor zcytor19

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- Number: US 7,608,452 B2
- Document ID: US7608452B2
- Status: Granted
- Kind: B2
- Application number: 11/539,064
- Filed: 2006-10-05
- Published: 2007-05-17
- Granted: 2009-10-27
- Earliest claimed: 2000-11-28
- Assignees: ZymoGenetics, Inc.
- Inventors: Scott R. Presnell; Theodore E. Whitmore; Francis J. Grant; Emily C. Costerison
- Web page: https://patentgrep.com/patent/US7608452B2

## CPC

- C07K 14/47: from mammals
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 11/06: Antiasthmatics
- A61P 13/12: of the kidneys
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 21/04: for myasthenia gravis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- A61P 31/18: for HIV
- A61P 33/00: Antiparasitic agents
- A61P 35/00: Antineoplastic agents
- A61P 37/02: Immunomodulators
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07K 14/715: for cytokines; for lymphokines; for interferons
- C07K 2319/00: Fusion polypeptide
- Y10T 436/143333: Saccharide [e.g., DNA, etc.]
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

## Claims

### Claim 1

An isolated polynucleotide comprising the nucleotide sequence as shown in SEQ ID NO:18 from nucleotide 61 to nucleotide 1560 or the RNA equivalent thereof.

### Claim 2 (depends on 1)

The isolated polynucleotide according to claim 1, wherein the polynucleotide comprises a stop codon at the carboxyl terminus.

### Claim 3 (depends on 1)

The isolated polynucleotide according to claim 1, wherein the polynucleotide comprises the nucleotide sequence as shown in SEQ ID NO: 18 from nucleotide 1 to nucleotide 1560.

### Claim 4 (depends on 1)

The isolated polynucleotide according to claim 1, wherein the polynucleotide comprises the nucleotide sequence as shown in SEQ ID NO: 18 from nucleotide 1 to nucleotide 1563.

### Claim 5 (depends on 1)

The isolated polynucleotide according to claim 1, wherein the polynucleotide consists of the nucleotide sequence.

### Claim 6

A vector comprising the nucleotide sequence as shown in SEQ ID NO: 18 from nucleotide 61 to nucleotide 1560.

### Claim 7 (depends on 6)

The vector according to claim 6, wherein the nucleotide sequence comprises a stop codon at the carboxyl terminus.

### Claim 8

An isolated host cell comprising a vector, wherein the vector comprises the nucleotide sequence as shown in SEQ ID NO: 18 from nucleotide 61 to nucleotide 1560.