# US 7,608,265 B2 · Treatment for bacterial infections

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- Number: US 7,608,265 B2
- Document ID: US7608265B2
- Status: Granted
- Kind: B2
- Application number: 11/630,926
- Filed: 2005-07-01
- Published: 2008-02-14
- Granted: 2009-10-27
- Earliest claimed: 2004-07-02
- Assignees: NeuTec Pharma PLC
- Inventors: James Peter Burnie; Ruth Christine Matthews; Tracey Carter
- Web page: https://patentgrep.com/patent/US7608265B2

## CPC

- C07K 16/1282: Clostridium (G)
- A61K 39/40: bacterial
- A61P 31/04: Antibacterial agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07K 2317/565: Complementarity determining region [CDR]
- C07K 2317/76: Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is concerned with compounds, medicaments and treatments for Clostridium difficile infection, together with novel isolated antibodies and their use in same. The present invention is also concerned with the treatment and prophylaxis of E. faecium and E. faecalis infection and provides medicaments and treatments for same.

## Claims

### Claim 1

An isolated antibody or antigen binding fragment thereof that binds acetyl-coA-acetyltransferase of Clostridium difficile, the antigen or antigen binding fragment thereof comprising:
(i) a heavy chain, wherein complementarity determining region 1 comprises the amino acid sequence of SEQ ID NO: 2, complementarity determining region 2 comprises the amino acid sequence of SEQ ID NO: 3 and complementarity determining region 3 comprises the amino acid sequence of SEQ ID NO: 4, and
(ii) a light chain, wherein complementarity determining region 1 comprises the amino acid sequence of SEQ ID NO: 17, complementarity determining region 2 comprises the amino acid sequence of SEQ ID NO: 18 and complementarity determining region 3 comprises the amino acid sequence of SEQ ID NO: 19.

### Claim 2 (depends on 1)

The antibody or antigen binding fragment thereof according to claim 1, wherein the heavy chain comprises the amino acid sequence of SEQ ID NO: 1.

### Claim 3 (depends on 1)

The antibody or antigen binding fragment thereof according to claim 1, wherein the light chain comprises the amino acid sequence of SEQ ID NO: 16.

### Claim 4 (depends on 1)

The antibody or antigen binding fragment thereof according to claim 1, wherein the antibody comprises the amino acid sequence of SEQ ID NO: 41.