# US 7,608,247 B2 · Use of outer membrane protein a in treatment/prevention/diagnosis of bacterial infection in central nervous system and/or peripheral blood circulation

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- Number: US 7,608,247 B2
- Document ID: US7608247B2
- Status: Granted
- Kind: B2
- Application number: 12/046,165
- Filed: 2008-03-11
- Published: 2009-09-17
- Granted: 2009-10-27
- Earliest claimed: 2008-03-11
- Assignees: Taipei Medical University
- Inventors: Yi-Yuan Yang; Hsueh-Hsia Wu; Sy-Jye Leu; I-Jen Huang; Neng-Yao Shih; Ko-Jiunn Liu; Mei-Ru Chen; Wen-Shyang Hsieh; Chi-Hsin Lee
- Web page: https://patentgrep.com/patent/US7608247B2

## CPC

- G01N 33/6893: {related to diseases not provided for elsewhere}
- A61K 38/164: {from bacteria}
- A61P 31/04: Antibacterial agents
- G01N 2800/26: Infectious diseases, e.g. generalised sepsis
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.

## Claims

### Claim 1

A method for the treatment of Escherichia coli infection in central nervous system and/or peripheral blood circulation in a mammal, which comprises administering to said mammal an effective amount of an outer membrane protein A (OmpA) of Escherichia coli.

### Claim 2 (depends on 1)

The method of claim 1, wherein the mammal is human.

### Claim 3 (depends on 1)

The method of claim 1, wherein the OmpA is a recombinant OmpA.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the OmpA is administrated orally or via intravenous injection.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the OmpA is administrated at an amount of 0.0001% to 10% by weight of OmpA.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the OmpA is administrated at an amount of 0.5% to 5% by weight of OmpA.

### Claim 7

A method for vaccinating a mammal to produce an antibody against Escherichia coli infection in central nervous system and/or peripheral blood circulation, which comprises administering to said mammal an effective amount of an OmpA of Escherichia coli.

### Claim 8 (depends on 7)

The method of claim 7, wherein the antibody is a polyclonal antibody.

### Claim 9 (depends on 7)

The method of claim 7, wherein the mammal is human.

### Claim 10 (depends on 7)

The method of claim 7, wherein the OmpA is a recombinant OmpA.

### Claim 11 (depends on 7)

The method according to claim 7, wherein the OmpA is administrated at an amount of 0.0001% to 10% by weight of OmpA.

### Claim 12 (depends on 7)

The method according to claim 7, wherein the OmpA is administrated at an amount of 0.5% to 5% by weight of OmpA.