# US 7,608,246 B2 · Apolipoprotein E as an adjuvant for lipid antigens

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- Number: US 7,608,246 B2
- Document ID: US7608246B2
- Status: Granted
- Kind: B2
- Application number: 11/516,017
- Filed: 2006-09-05
- Published: 2007-05-17
- Granted: 2009-10-27
- Earliest claimed: 2005-09-02
- Assignees: The Brigham and Women's Hospital, Inc.
- Inventors: Peter van den Elzen; Michael B. Brenner
- Web page: https://patentgrep.com/patent/US7608246B2

## CPC

- A61K 39/0012: {Lipids; Lipoproteins}
- A61K 31/739: Lipopolysaccharides
- A61K 2039/55516: {Proteins; Peptides}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention is directed to pharmaceutical compositions that contain a combination of apolipoprotein E and an antigenic lipid. The compositions may be administered to a subject for the purpose of inducing an immune response against the lipid and in immunization protocols.

## Claims

### Claim 1

A method of inducing the production of antibodies against an antigenic lipid, comprising administering to a subject capable of antibody production a composition comprising:
a) said antigenic lipid; and
b) apolipoprotein E in an amount that, together with said antigenic lipid, is sufficient to induce production of said antibodies.