# US 7,608,101 B2 · Resorption-controllable medical implants > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,608,101 B2 - Document ID: US7608101B2 - Status: Granted - Kind: B2 - Application number: 11/897,016 - Filed: 2007-08-28 - Published: 2008-12-25 - Granted: 2009-10-27 - Earliest claimed: 2002-04-23 - Assignees: Boston Scientific Scimed, Inc. - Inventors: Barry N. Gellman; Jianmin Li - Web page: https://patentgrep.com/patent/US7608101B2 ## CPC - A61L 29/085: {Macromolecular materials} - A61L 27/34: Macromolecular materials - A61L 27/44: having a macromolecular matrix - A61L 27/58: Materials at least partially resorbable by the body - A61L 29/126: {having a macromolecular matrix} - A61L 29/148: {Materials at least partially resorbable by the body} - A61L 29/18: Materials at least partially X-ray or laser opaque - A61L 31/10: Macromolecular materials - A61L 31/125: {having a macromolecular matrix} - A61L 31/148: {Materials at least partially resorbable by the body} - A61L 31/18: Materials at least partially X-ray or laser opaque - A61M 25/0045: {multi-layered, e.g. coated (coating materials A61L29/08)} - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates. ## Claims ### Claim 1 A bioresorbable medical implant for use in a mammal comprising: a. a first layer comprising a first bioresorbable material being substantially free from resorbable particles; and b. a second layer disposed relative to the first layer, the second layer comprising a second bioresorbable material and resorbable particles of a first kind that are dispersed within the second bioresorbable material, wherein the resorbable particles increase the resorption rate of the second bioresorbable material in the mammal, wherein each of the first and the second bioresorbable materials comprises an ionically crosslinked polymeric material and the resorbable particles are comprised of the same ionically crossliniked polymer material of one or both of the first or second bioresorbable material but wherein a molecular weight, crosslinking ratio, or crosslinking ions associated with the resorbable particles is different from that associated with the first or second bioresorbable material, wherein the medical implant comprises an interior surface and an exterior surface and wherein the first layer forms the interior surface and the second layer forms the exterior surface. ### Claim 2 (depends on 1) The medical implant of claim 1, further comprising a third layer disposed adjacent the second layer, the third layer comprising a third bioresorbable material. ### Claim 3 (depends on 2) The medical implant of claim 2, wherein the third layer comprising a third bioresorbable material and resorbable particles of a second kind are dispersed within the third bioresorbable material. ### Claim 4 (depends on 2) The medical implant of claim 2, wherein the first bioresorbable material, the second bioresorbable material, and the third bioresorbable material are identical. ### Claim 5 (depends on 4) The medical implant of claim 4, wherein the bioresorbable material is a crosslinked alginate. ### Claim 6 (depends on 3) The medical implant of claim 3, wherein the resorbable particles of the first kind and the resorbable particles of the second kind are identical. ### Claim 7 (depends on 5) The medical implant of claim 5, wherein the resorbable particles comprise a radiopacifier. ### Claim 8 (depends on 2) The medical implant of claim 2, further comprising one or more additional layers disposed relative to the first, the second, and the third layers, each of the one or more additional layers comprising a bioresorbable material, at least one of the one or more additional layers further comprising resorbable particles of a third kind dispersed within the bioresorbable material. ### Claim 9 (depends on 8) The medical implant of claim 8, wherein the bioresorbable material of the one or more additional layers, the first bioresorbable material, the second bioresorbable material, and the third bioresorbable material are identical. ### Claim 10 (depends on 1) The medical implant of claim 1, wherein the ionically crossliniked polymeric material comprises at least one polymer or copolymer made from at least one member of the group consisting of polyacrylic acids, polymethacrylic acid, polyethylene amine, polysaccharides, alginic acid, pectinic acids, carboxy methyl cellulose, hyaluronic acid, heparin, chitosan, carboxymethyl chitosan, carboxymethyl starch, carboxymethyl dextran, heparin sulfate, chondroitin sulfate, cationic starch, and salts thereof. ### Claim 11 (depends on 1) The medical implant of claim 1, wherein the ionically crossliniked polymeric material is an ionically crossliniked polymer hydrogel and has a water content of less than about 90% by weight. ### Claim 12 (depends on 1) The medical implant of claim 1, wherein the first and second layers form one of a stent, a catheter, a cannula, a plug, a constrictor, a sheet, a filler, a bone anchor, a plate, a rod, a seed, a tube, or a portion thereof. ### Claim 13 (depends on 1) The medical implant of claim 1, wherein the medical implant comprises a resorption profile having a plurality of differing resorption rates. ### Claim 14 (depends on 13) The medical implant of claim 13, wherein the resorption rates vary as a function of time. ### Claim 15 (depends on 13) The medical implant of claim 13, wherein the resorption rates vary as a function of a physical dimension of the implant. ### Claim 16 (depends on 1) The medical implant of claim 1, wherein the second layer is disposed adjacent the first layer. ### Claim 17 (depends on 1) The medical implant of claim 1, wherein the resorption profile is non-uniform.