# US 7,607,208 B2 · Method of making a medicated stent

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- Number: US 7,607,208 B2
- Document ID: US7607208B2
- Status: Granted
- Kind: B2
- Application number: 10/431,557
- Filed: 2003-05-07
- Published: 2003-10-16
- Granted: 2009-10-27
- Earliest claimed: 1996-12-30
- Assignees: Sorin Biomedica Cardio S.p.A.
- Inventors: Maria Curcio; Giovanni Rolando; Franco Vallana
- Web page: https://patentgrep.com/patent/US7607208B2

## CPC

- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61F 2/86: Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61L 31/022: {Metals or alloys}
- A61L 31/084: {Carbon; Graphite}
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61L 33/025: {Carbon; Graphite}
- A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)}
- A61F 2250/0025: differing in roughness
- A61F 2250/0068: the pharmaceutical product being in a reservoir
- A61F 2310/00574: Coating or prosthesis-covering structure made of carbon, e.g. of pyrocarbon
- A61F 2310/0058: Coating made of diamond or of diamond-like carbon DLC
- A61L 2300/416: Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A61L 2300/42: Anti-thrombotic agents, anticoagulants, anti-platelet agents
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- Y10T 29/49885: with coating before or during assembling
- Y10T 29/49995: Shaping one-piece blank by removing material
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A stent has surface sculpturing, preferably on its outer surface only, having, for example, microspheres, having the function of increasing the actual geometric surface area of the stent, of creating undercuts and roughness to encourage the application of coatings of active or activatable agents, as well as of improving the attachment of the stent to the blood vessel wall.

## Claims

### Claim 1

A method of making a medicated stent comprising:
providing a tubular body portion having an inner surface and an outer surface and defining a stent thickness therebetween;
laser cutting a plurality of apertures in the tubular body portion extending from the outer surface to the inner surface, the apertures being positioned such that the tubular body portion is expandable from a radially-contracted position to a radially-expanded position;
laser cutting a plurality of incisions in the outer surface of the tubular body portion, the incisions being defined at least in part by first and second side walls and a bottom surface between the side walls, a radial distance between the outer surface of the tubular body portion and the bottom surface of the incisions comprising an incision depth, the incision depth being less than the stent thickness;
coating the tubular body of the stent with a biocompatible carbon material; and
after the coating step, applying an outer coating in the plurality of incisions, the outer coating including an active agent.

### Claim 2 (depends on 1)

The method of claim 1 wherein the step of laser cutting the apertures is performed before the step of laser cutting the incisions.

### Claim 3 (depends on 1)

The method of claim 1 wherein the step of laser cutting the incisions is performed before the step of laser cutting the apertures.

### Claim 4 (depends on 1)

The method of claim 1 wherein the active agent is an antithrombogenic agent.

### Claim 5

A method of making a medicated stent comprising:
providing a tubular body portion having an inner surface and an outer surface and defining a stent thickness therebetween;
laser cutting a plurality of apertures in the tubular body portion extending from the outer surface to the inner surface, the apertures being positioned such that the tubular body portion is expandable from a radially-contracted position to a radially-expanded position;
laser cutting a plurality of incisions in the outer surface of the tubular body portion, the incisions being defined at least in part by first and second side walls and a bottom surface between the side walls, a radial distance between the outer surface of the tubular body portion and the bottom surface of the incisions comprising an incision depth, the incision depth being less than the stent thickness; and
coating the outer surface of the tubular body portion such that the coating is deposited in the plurality of incisions, the coating being the outermost layer of the medicated stent, the coating comprising an active agent.

### Claim 6

A method of making a medicated stent for deployment at a treatment site in a vessel of a human body comprising:
providing a tubular body portion having an inner surface and an outer surface and defining a stent thickness therebetween;
laser cutting a plurality of apertures in the tubular body portion extending from the outer surface to the inner surface, the apertures being positioned such that the tubular body portion is expandable from a radially-contracted position to a radially-expanded position;
laser cutting a plurality of incisions in the outer surface of the tubular body portion, the incisions being defined at least in part by first and second side walls and a bottom surface between the side walls, a radial distance between the outer surface of the tubular body portion and the bottom surface of the incisions comprising an incision depth, the incision depth being less than the stent thickness; and
depositing an active agent in the plurality of incisions in a manner that results in direct contact between the active agent and the walls of the vessel when the medicated stent is deployed at the treatment site in the vessel.

### Claim 7

A method of making a medicated stent for deployment at a treatment site in a vessel of a human body comprising:
providing a tubular body portion having an inner surface and an outer surface and defining a stent thickness therebetween;
laser cutting a plurality of apertures in the tubular body portion extending from the outer surface to the inner surface, the apertures being positioned such that the tubular body portion is expandable from a radially-contracted position to a radially-expanded position;
laser cutting a plurality of incisions in the outer surface of the tubular body portion, the incisions being defined at least in part by first and second side walls and a bottom surface between the side walls, a radial distance between the outer surface of the tubular body portion and the bottom surface of the incisions comprising an incision depth, the incision depth being less than the stent thickness; and
depositing a coating including an active agent in the plurality of incisions such that when the medicated stent is deployed at the treatment site in the vessel the coating is in direct contact with a wall of the vessel.