Back to results
US 7,605,916 B2Granted
Online analyte detection by surface enhanced Raman scattering (SERS)
AssigneeIntel Corporation
InventorsJingwu Zhang, Sarah M. Ngola, Xing Su
Life of this patent
Estimating the term…
Abstract
Devices and methods for separating and detecting analytes in a sample. The separation can be accomplished utilizing capillary electrophoresis (CE) or high-performance liquid chromatography (HPLC). The detection can be accomplished by surface enhanced Raman scattering.
Claims40
A device comprising:
- a separation cell configured to separate analytes in a sample;
- and
- a surface enhanced Raman scattering (SERS) cell comprising SERS active particles, wherein the separation cell and the SERS cell are connected by a fluid connection to permit analytes in the sample to flow through the separation cell into the SERS cell, wherein the SERS cell is a flow-through SERS cell and the device is an on-line detection device to detect the analytes in the sample as the analytes pass through the SERS cell.
A device comprising:
- a separation cell comprising surface enhanced Raman scattering (SERS) active particles, wherein the cell is configured to separate analytes in a sample flowing through the separation cell;
- and
- a SERS detector configured to collect the Raman spectra of analytes within the separation cell.
A device comprising:
- a separation cell configured for capillary electrophoresis (CE);
- and
- a Raman detector configured to collect the Raman spectra of analytes flowing through the separation cell, wherein the separation cell comprises SERS active particles.
A device comprising:
- a separation cell configured to perform capillary or nanobore high-performance chromatography (HPLC);
- and
- a Raman detector configured to collect the Raman spectra of analytes flowing through the separation cell, wherein the separation cell comprises SERS active particles.
A method of collecting the Raman spectra of analytes in a sample comprising:
- introducing a sample into a cell configured to perform capillary electrophoresis (CE);
- separating a sample comprising analytes by CE;
- and
- collecting the Raman spectra of analytes in a sample using a Raman detector, wherein the Raman detector is located in-line with the cell configured to perform CE, wherein the cell comprises SERS active particles.
1 more element
A method of collecting the Raman spectra of analytes in a sample comprising:
- introducing a sample into a cell configured to perform high-performance chromatography (HPLC);
- separating a sample comprising analytes by HPLC;
- and
- collecting the Raman spectra of analytes in a sample using a Raman detector, wherein the cell comprises SERS active particles.
1 more element
Dependencies are inferred from the claim text.