A semiconductor device structure comprising at least one SRAM cell located in a substrate, wherein said at least one SRAM cell comprises at least two pull-up transistors, two pull-down transistors, and two pass-gate transistors, wherein said substrate comprises a hybrid crystal orientation substrate having a first crystallographic orientation region that is connected through an active region that is in direct physical contact to a second crystallographic orientation region, the first crystallographic orientation region having an upper surface that is coplanar with an upper surface of the second crystallographic orientation region, and said first crystallographic region and said second crystallographic region comprise substrate materials of different composition, wherein the two pull-down transistors are located in the first crystallographic orientation region, and the two pass-gate transistors are located in the second crystallographic orientation region, and wherein current carriers in the pull-down transistors have a higher mobility than those in the pass-gate transistors.