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US 7,605,288 B2Granted
Heat shock protein 90 inhibitors
AssigneeUniversity of Kansas
InventorsBrian Blagg, Gang Shen, Randell C. Clevenger
Life of this patent
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Abstract
Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
Claims16
Compounds corresponding to Formula I:
- wherein A is hydrogen, halogen, lower alkyl, lower alkoxy, aryl, aralyl, or allyl;
- wherein B is hydroxy, amino, halogen, lower alkoxy, or aralkoxy;
- wherein C is hydroxy, amino, or lower alkoxy;
- wherein D is alkyl, oxygen, amino, sulfanyl, sulfenyl, or sulfonyl;
- wherein E is halogen, hydroxy, lower alkoxy, amino, or allyl amine;
- wherein F is hydroxy, halogen, thiol, lower alkoxy, amino or oxidized to form a ketone;
- wherein G is amino, thiol, hydroxy, lower alkoxy, or oxidized to form a ketone;
- wherein I is amino;
- wherein J is carbonyl;
- wherein M is alkyl or cycloalkyl;
- wherein K is alkyl or cycloalkyl;
- and
- wherein R is hydrogen or alkyl.
10 more elements
Dependencies are inferred from the claim text.