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US 7,605,282 B2Granted
Process for the preparation of an oxaliplatin preparation
AssigneeVuab Pharma A.S.
InventorsVladimir Kysilka, Tomas Kalisz, Petr Kacer
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Abstract
The present invention relates to an improved process for the preparation of oxaliplatin, the obtained oxaliplatin preparation and its use in cancer therapy.
Claims20
A process for preparing oxaliplatin of the structural formula I:
- comprising the following steps:
- a) reacting a (SP-4-2)dihalogen-[(1R,2R)-1,2-cyclohexanediamine-kN,kN′]platinum(II) complex with a silver salt in an aqueous medium to obtain an aqueous medium to obtain an aqueous solution containing ionic platinum(II)diaqua-complex and a solid phase,
- b) removing the solid phase,
- c) adjusting the pH-value of the aqueous solution containing the ionic platinum(II)diaqua-complex obtained in step b) to a pH-value of 9.5, to obtain an alkaline solution comprising a (SP-4-2)dihydroxo-[(1R,2R)-1,2-cyclohexanediamine-kN,kN′]platinum(II) complex (DACHPt(OH)2),
- d) purifying the alkaline solution to obtain a purified alkaline solution and
- e) adding oxalic acid and/or an oxalic salt to the purified alkaline solution obtained in step d) to obtain purified oxaliplatin.
3 more elements
A process for preparing a stabilized non-ionic compound (SP-4-2)dihydroxo-[(1R,2R)-1,2-cyclohexanediamine-kN,kN′]platinum(II) complex (DACHPt(OH)2), comprising the steps
- a) reacting a (SP-4-2)dihalogen-[(1R,2R)-1,2-cyclohexanediamine-kN,kN′]platinum(II) complex with a silver salt in an aqueous medium to obtain an aqueous solution containing an ionic platinum(II)diaqua-complex and a solid phase,
- b) removing the solid phase,
- c) adjusting the pH-value of the aqueous solution containing the ionic platinum(II)diaqua-complex obtained in step b) to a pH-value of 9.5 to 13, to obtain an alkaline solution comprising (SP-4-2)dihydroxo-[(1R,2R)-1,2-cyclohexanediamine-kN,kN′]platinum(II) complex (DACHPt(OH)2), and optionally
- d) purifying the alkaline solution to obtain a purified alkaline solution comprising the purified DACHPt(OH)2 and isolating them therefrom.
1 more element
Dependencies are inferred from the claim text.