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US 7,605,274 B2Granted
Carvedilol
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsJean Hildesheim, Sergei Fine, Judith Aronhime, Ben-Zion Dolitzky, Shoshana Ben-Valid, Ilan Kor-Sade
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Abstract
This invention relates to an improved process of preparing carvedilol, as well as a new crystalline hydrate and solvate and forms of carvedilol, processes for the manufacture thereof, and pharmaceutical compositions thereof.
Claims12
A method for preparing crystalline carvedilol Form III, comprising the steps of:
- a) dissolving carvedilol in a solvent to form a solvent solution;
- and,
- b) precipitating crystalline carvedilol Form III from the solvent solution using water as an anti-solvent;
- wherein crystalline carvedilol Form III is characterized by PXRD peaks at about 8.4+0.2, 17.4+0.2, and 22.0+0.2 degrees two-theta.
1 more element
Dependencies are inferred from the claim text.