Urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use

A pharmaceutical composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier

• wherein:
• wherein:
• Y is an oxygen or sulphur atom,
• Z is —C(═CH2)—, —CH(CH3)—
• R1 is an optionally substituted morpholinyl radical or a saturated diamine radical of formula:
• radical,
• wherein the continuous arc indicates that the two nitrogen atoms form a monocyclic, heterocyclic, saturated, optionally substituted radical constituted by at most 8 members, the nitrogen atoms optionally being consecutive on the ring thus formed;
• X is a linear or branched alkylene radical containing at most 6 carbon atoms;
• R4 is the hydrogen atom, an esterified carboxy radical, or an optionally substituted linear or branched alkyl radical containing at most 4 carbon atoms;,
• R5 and R6 which could be identical or different, are the hydrogen atom, an optionally substituted linear or branched alkyl radical containing at most 4 carbon atom;
• R2 is a linear or branched alkyl radical containing at most 6 carbon atoms substituted by one or more identical or different radicals chosen from the aryl or heteroaryl radicals themselves optionally substituted;
• R3 is a linear or branched alkyl radical containing at most 6 carbon atoms, cycloalkyl containing at most 12 members, aryl, heteroaryl, arylailcyl or heteroarylalkyl in which the alkyl radical is linear or branched containing at most 4 carbon atoms, all these radicals being optionally substituted.

A method of treating hyperparathyroidism comprising administering to a patient in need thereof a compound of Formula I

• or a pharmaceutically acceptable salt thereof, wherein:
• Y is an oxygen or sulphur atom,
• Z is —C(═CH2)—, —CH(CH3)— or —CH2—;
• R1 is an optionally substituted morpholinyl radical or a saturated diamine radical of formula:
• radical
• wherein the continuous are indicates that the two nitrogen atom form a monoeyelic heteroeyelic, saturated, optionally substituted radical constituted by at most 8 member, the nitrogen atom optionally being consecutive on the ring thus formed;
• X is a carbonyl, or linear or branched alkylene radical containing at most 6 carbon atoms;
• R4, R5 and R6, which could be identical or different, are the hydrogen atom, an esterified carboxy radical, a benzyl radical, an optionally substituted linear or branched alkyl radical containing at most 4 carbon atoms, an optionally substituted cycloalkyl radical containing at most 6 member, an optionally substituted aryl radical, or an optionally substituted arylalkyl radical;
• R2 is a linear or branched alkyl radical containing at most 6 carbon atoms substituted by one or more identical or different radical chosen from the aryl or heteroaryl radicals themselves optionally substituted;
• R3 is a linear or branched alkyl radical containing at most 6 carbon atoms, cycloalkyl containing at most 12 members, aryl, heteroaryl, arylalkyl or, heteroarylalkyl in which the alkyl radical is linear or branched cantaining at most 4 carbon atoms, all the radicals being optionally substituted.