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US 7,605,255 B2Granted
Non-animal based lactose
AssigneeAlberta Research Council
InventorsDonna Day, Minghui Du, Roberto Mendez, Darol Maunder
Life of this patent
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Abstract
A synthetic procedure for the preparation of non-animal based lactose from 4′-epimeric analogue of lactose by use of orthogonal protecting groups, formation of a suitable leaving group at the 4′-position, stereochemical inversion by nucleophilic attack and deprotection.
Claims8
A method for the synthesis of lactose from a 4′-epimeric analog of lactose by use of orthogonal protecting groups, formation of a suitable leaving group at the 4′-position, stereochemical inversion by nucleophilic attack and deprotection.
A method of synthesizing lactose, comprising the steps of:
- a) protecting at least the 4′-epimeric functional group of a 4′-epimeric analog of lactose with a first protecting group;
- b) protecting all other hydroxyl groups with a second protecting group;
- c) removal of the first protecting group;
- d) conversion of the 4′-epimeric functional group into a suitable leaving group;
- e) nucleophilic attack leading to stereochemical inversion at the 4′-position;
- and
- f) removal of the protecting groups;
- and wherein the first and second protecting groups are orthogonal.
5 more elements
Dependencies are inferred from the claim text.