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AssigneeAlnylam Pharmaceuticals, Inc.
InventorsPamela Tan, Birgit Bramlage, Maria Frank-Kamenetsky, Kevin Fitzgerald, Akin Akinc, Victor E. Kotelianski
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The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the proprotein convertase subtilisin kexin 9 (PCSK9) gene, comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; and methods for treating diseases caused by PCSK9 gene expression by using the pharmaceutical composition.
A double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human proprotein convertase subtilisin kexin 9 (PCSK9) gene in a cell, wherein said dsRNA comprises at least two sequences that are complementary to each other and wherein a sense strand comprises a first sequence and an antisense strand comprises a second sequence comprising at least 15 contiguous nucleotides of SEQ ID NO:1230.
A pharmaceutical composition for inhibiting the expression of the proprotein convertase subtilisin kexin 9 (PCSK9) gene in an organism, comprising a dsRNA and a pharmaceutically acceptable carrier, wherein the dsRNA comprises at least two sequences that are complementary to each other and wherein a sense strand comprises a first sequence and an antisense strand comprises a second sequence comprising at least 15 contiguous nucleotides of SEQ ID NO:1230 and wherein said dsRNA is capable of causing a decrease in serum lipid levels.
Dependencies are inferred from the claim text.