Genes differentially expressed in breast cancer
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsJoerg Kaufmann, Greg Harrowe, Christoph Reinhard, Sanmao Kang
Life of this patent
Estimating the term…
Abstract
A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.
Claims19
An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding amino acids from 1 to 273 of SEQ ID NO:2;
- (b) a polynucleotide encoding amino acids from 2 to 273 of SEQ ID NO:2;
- (c) a polynucleotide encoding amino acids from 26 to 273 of SEQ ID NO:2;
- and
- (d) the polynucleotide complement of the complete polynucleotide of (a), (b), or (c).
An isolated nucleic acid molecule comprising a polynucleotide encoding a polypeptide wherein, except for no more than 5 conservative amino acid substitutions, said polypeptide has an amino acid sequence selected from the group consisting of:
- (a) amino acids 1 to 273 of SEQ ID NO:2;
- (b) amino acids 2 to 273 of SEQ ID NO:2;
- and
- (c) amino acids 26 to 273 of SEQ ID NO:2.
An isolated nucleic acid molecule comprising a polynucleotide at least 95% identical to a polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding amino acids from 1 to 273 of SEQ ID NO:2;
- (b) a polynucleotide encoding amino acids from 2 to 273 of SEQ ID NO:2;
- (c) a polynucleotide encoding amino acids from 26 to 273 of SEQ ID NO:2;
- and
- (d) the full polynucleotide complement of the complete polynucleotide of (a), (b), or (c).
An isolated nucleic acid molecule comprising a polynucleotide encoding a polypeptide at least 95% identical to SEQ ID NO:2, or the full complement of the complete polynucleotide.
Dependencies are inferred from the claim text.