Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom
AssigneeLaboratori Derivati Organici S.p.A.
InventorsLuigi De Ambrosi, Donata Bensi, Elena Vismara
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Abstract
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of UVC radiation. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.
Claims7
A dynamic irradiation process for the depolymerization of heparin wherein the depolymerized heparin has a Mw less than or equal to 50% of the original Mw of said heparin prior to depolymerization, said dynamic irradiation process comprising exposing said heparin in solution at a concentration between 2 and 25% w/v to UV radiation having a peak of from 245 nm to 260 nm for a sufficient time to reduce the Mw of the depolymerized heparin by at least 50% as compared with the Mw of said heparin prior to said exposure to UV radiation.
Dependencies are inferred from the claim text.