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US 7,605,234 B2Granted
Specific binding proteins including antibodies which bind to the necrotic centre of tumours, and uses thereof
AssigneePeregrine Pharmaceuticals, Inc.
InventorsAndrew James Williams, Philip Ronald Tempest, Thor Las Holtet, Helen Jackson
Life of this patent
Estimating the term…
Abstract
Specific binding members, featuring certain residues of the third CDR of the antibody NH576 (portions of SEQ ID NO:2) are provided, together with their use in methods of treatment and diagnosis.
Claims18
An isolated antibody comprising a heavy chain variable domain comprising an amino acid sequence as set forth as residues 31-36, 51-66 and 99 to 106 of SEQ ID NO:
- 2;
- and further comprising a light chain variable domain comprising an amino acid sequence as set forth as residues 23-33, 49-55 and 88 to 98 of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.