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US 7,605,180 B2Granted
Nateglinide-containing preparation
AssigneeAjinomoto Co., Inc.
InventorsNobutaka Ninomiya, Chisato Makino, Akira Yabuki
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Abstract
The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the nateglinide is amorphous.
Claims20
A method for producing an amorphous nateglinide-containing preparation, which comprises:
- mixing nateglinide crystals with at least one hydrophilic material selected from the group consisting of a water-soluble polymer, a water-swelling polymer, a sugar alcohol, a salt, and mixtures thereof, to obtain a mixture;
- and
- subjecting the resulting said mixture to melt-kneading with heating and grinding with cooling,
- wherein said water-soluble polymer or said water-swelling polymer is at least one member selected from the group consisting of a polyvinyl pyrrolidone compound, a polysaccharide, a polyacrylic acid compound, a polylactic acid compound, a polyoxyethylene compound, a polyvinyl alcohol compound, a surfactant, and mixtures thereof.
1 more element
Dependencies are inferred from the claim text.